Meiosis: the chromosomal foundation of reproduction.

Authors

Ewelina Bolcun-Filas, The Jackson LaboratoryFollow
Mary Ann Handel, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

7-1-2018

JAX Source

Biol Reprod 2018 Jul 1; 99(1):112-126

Volume

99

Issue

1

First Page

112

Last Page

126

ISSN

1529-7268

PMID

29385397

DOI

https://doi.org/10.1093/biolre/ioy021

Abstract

Meiosis is the chromosomal foundation of reproduction, with errors in this important process leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the founding of the Society for the Study of Reproduction, the important chromosomal structures and dynamics contributing to genomic integrity across generations are highlighted. Critical unsolved biological problems are identified, and the advances that will lead to their ultimate resolution are predicted.

Comments

We are indebted to Ricardo Benavente, University of Wurzburg, for generously providing images for Figure 3. We thank the members of our laboratories for productive discussions. And finally, meiosis is a gratifyingly productive and rapidly moving research area, and we offer both thanks and apologies to the many excellent scientists who have contributed but are not cited in this somewhat idiosyncratic and personal review.

Recommended Citation

Bolcun-Filas E, Handel M. Meiosis: the chromosomal foundation of reproduction. Biol Reprod 2018 Jul 1; 99(1):112-126