Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation.
Sci Rep 2018 Nov 9; 8(1):16607
Chronic periodontitis (CP) is a microbial dysbiotic disease linked to increased risk of oral squamous cell carcinomas (OSCCs). To address the underlying mechanisms, mouse and human cell infection models and human biopsy samples were employed. We show that the 'keystone' pathogen Porphyromonas gingivalis, disrupts immune surveillance by generating myeloid-derived dendritic suppressor cells (MDDSCs) from monocytes. MDDSCs inhibit CTLs and induce FOXP3 + T
Arjunan, Pachiappan; Meghil, Mohamed M; Pi, Wenhu; Xu, Jinxian; Lang, Liwei; El-Awady, Ahmed; Sullivan, William; Rajendran, Mythilypriya; Rabelo, Mariana Sousa; Wang, Tong; Tawfik, Omnia K; Kunde-Ramamoorthy, Govindarajan; Singh, Nagendra; Muthusamy, Thangaraju; Susin, Cristiano; Teng, Yong; Arce, Roger M; and Cutler, Christopher W, "Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting both Immune Suppression and Oncogenic Cell Proliferation." (2018). Faculty Research 2018. 221.
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