Document Type

Article

Publication Date

1-1-2018

Publication Title

eNeuro

Keywords

JMG, Action Potentials, Animals, Conditioning, Classical, Electric Stimulation, Electroshock, Environment, Excitatory Amino Acid Antagonists, Fear, GABA Antagonists, Hippocampus, In Vitro Techniques, Kynurenic Acid, Male, Memory, Mice, Mice, Inbred C57BL, Neurons, Pyridazines

JAX Source

eNeuro . 2018 Jan 4;5(6):ENEURO.0484-18.2018

Volume

5

Issue

6

ISSN

2373-2822

PMID

30627661

DOI

10.1523/ENEURO.0484-18.2018

Grant

This work was supported by the NIH Grant R01AG054180 (to C.C.K.), the NIH Grant R21AG048446 (to C.C.K.), the Evnin Family (C.C.K.), the Alzheimer’s Association Grant AARF 18-565506 (to A.R.D.), and the NIH Grant F31AG050357 (to S.M.N.).

Abstract

The subiculum is the main target of the hippocampal region CA1 and is the principle output region of the hippocampus. The subiculum is critical to learning and memory, although it has been relatively understudied. There are two functional types of principle neurons within the subiculum: regular spiking (RS) and burst spiking (BS) neurons. To determine whether these cell types are differentially modified by learning-related experience, we performed whole-cell patch clamp recordings from male mouse brain slices following contextual fear conditioning (FC) and memory retrieval relative to a number of control behavioral paradigms. RS cells, but not BS cells, displayed a greater degree of experience-related plasticity in intrinsic excitability measures [afterhyperpolarization (AHP), input resistance (R

Comments

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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