Document Type

Article

Publication Date

4-23-2018

JAX Source

Case Rep Oncol 2018 Mar 27; 11(1):196-205.

PMID

29681821

DOI

https://doi.org/10.1159/000487882

Grant

Harold Alfond Foundation, Maine Cancer Genetics Initiative

Abstract

Molecular profiling of urothelial cancers for therapeutic and prognostic potential has been very limited due to the absence of cancer-specific targeted therapies. We describe here 2 clinical cases with a histological diagnosis of an invasive sarcomatoid and a poorly differentiated carcinoma favoring urothelial with some neuroendocrine differentiation, two of the rarer types of urothelial cancers, which were evaluated for mutations in 212 genes for single-nucleotide variants and copy-number variants and 53 genes for fusions associated with solid tumors. In both cases, we identified variants in 2 genes, Case Rep Oncol 2018 Mar 27; 11(1):196-205.

Comments

This open access article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)

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