Case Rep Oncol 2018 Mar 27; 11(1):196-205.
Harold Alfond Foundation, Maine Cancer Genetics Initiative
Molecular profiling of urothelial cancers for therapeutic and prognostic potential has been very limited due to the absence of cancer-specific targeted therapies. We describe here 2 clinical cases with a histological diagnosis of an invasive sarcomatoid and a poorly differentiated carcinoma favoring urothelial with some neuroendocrine differentiation, two of the rarer types of urothelial cancers, which were evaluated for mutations in 212 genes for single-nucleotide variants and copy-number variants and 53 genes for fusions associated with solid tumors. In both cases, we identified variants in 2 genes, Case Rep Oncol 2018 Mar 27; 11(1):196-205.
Hesse, Andrew N; Fabricius, William; Thomas, Christian A; Gaindh, Ramesh; Christman, Robert; Selvam, Pavalan; Prego, Matthew; Lewis, Gregory; Uvalic, Jasmina; Bergeron, Daniel; Burns, Shelbi; Sisson, Bridgette; Kelly, Kevin; Rueter, Jens; and Reddi, Honey V, "Genomic Profiling of Two Histologically Distinct Rare Urothelial Cancers in a Clinical Setting to Identify Potential Therapeutic Options for Treatment and Management of Disease." (2018). Faculty Research 2018. 97.