High-Diversity Mouse Populations for Complex Traits.

Authors

Michael C Saul, The Jackson LaboratoryFollow
Vivek M. Philip, The Jackson LaboratoryFollow
Laura G Reinholdt, The Jackson LaboratoryFollow
Center for Systems Neurogenetics of Addiction
Elissa J Chesler, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

7-2019

Keywords

JMG

JAX Source

Trends Genet 2019 Jul; 35(7):501-514

Volume

35

Issue

7

First Page

501

Last Page

514

ISSN

0168-9525

PMID

31133439

DOI

https://doi.org/10.1016/j.tig.2019.04.003

Grant

CA034196,DA039841, DA037927

Abstract

Contemporary mouse genetic reference populations are a powerful platform to discover complex disease mechanisms. Advanced high-diversity mouse populations include the Collaborative Cross (CC) strains, Diversity Outbred (DO) stock, and their isogenic founder strains. When used in systems genetics and integrative genomics analyses, these populations efficiently harnesses known genetic variation for precise and contextualized identification of complex disease mechanisms. Extensive genetic, genomic, and phenotypic data are already available for these high-diversity mouse populations and a growing suite of data analysis tools have been developed to support research on diverse mice. This integrated resource can be used to discover and evaluate disease mechanisms relevant across species.

Recommended Citation

Saul M, Philip VM, Reinholdt L, of Addiction CN, Chesler E. High-Diversity Mouse Populations for Complex Traits. Trends Genet 2019 Jul; 35(7):501-514