Histone methyltransferase PRDM9 is not essential for meiosis in male mice.
Genome Res 2019 Jul; 29(7):1078-1086
A hallmark of meiosis is the rearrangement of parental alleles to ensure genetic diversity in the gametes. These chromosome rearrangements are mediated by the repair of programmed DNA double-strand breaks (DSBs) as genetic crossovers between parental homologs. In mice, humans, and many other mammals, meiotic DSBs occur primarily at hotspots, determined by sequence-specific binding of the PRDM9 protein. Without PRDM9, meiotic DSBs occur near gene promoters and other functional sites. Studies in a limited number of mouse strains showed that functional PRDM9 is required to complete meiosis, but despite its apparent importance,
Mihola, Ondrej; Pratto, Florencia; Brick, Kevin; Linhartova, Eliska; Kobets, Tatyana; Flachs, Petr; Baker, Christopher L.; Sedlacek, Radislav; Paigen, Kenneth; Petkov, Petko M.; Camerini-Otero, R Daniel; and Trachtulec, Zdenek, "Histone methyltransferase PRDM9 is not essential for meiosis in male mice." (2019). Faculty Research 2019. 155.