Title

Histone methyltransferase PRDM9 is not essential for meiosis in male mice.

Document Type

Article

Publication Date

7-2019

Keywords

JMG

JAX Source

Genome Res 2019 Jul; 29(7):1078-1086

PMID

31186301

DOI

https://doi.org/10.1101/gr.244426.118

Grant

GM099640,GM078452

Abstract

A hallmark of meiosis is the rearrangement of parental alleles to ensure genetic diversity in the gametes. These chromosome rearrangements are mediated by the repair of programmed DNA double-strand breaks (DSBs) as genetic crossovers between parental homologs. In mice, humans, and many other mammals, meiotic DSBs occur primarily at hotspots, determined by sequence-specific binding of the PRDM9 protein. Without PRDM9, meiotic DSBs occur near gene promoters and other functional sites. Studies in a limited number of mouse strains showed that functional PRDM9 is required to complete meiosis, but despite its apparent importance,

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