Title

Vascular Inflammation Risk Factors in Retinal Disease.

Document Type

Article

Publication Date

9-15-2019

Keywords

JMG

JAX Source

Annu Rev Vis Sci 2019; 5:99-122

PMID

31226014

DOI

https://doi.org/10.1146/annurev-vision-091517-034416

Grant

EY027305,EY027894,EY027701,AG051496

Abstract

Inflammation of the blood vessels that serve the central nervous system has been increasingly identified as an early and possibly initiating event among neurodegenerative conditions such as Alzheimer's disease and related dementias. However, the causal relevance of vascular inflammation to major retinal degenerative diseases is unresolved. Here, we describe how genetics, aging-associated changes, and environmental factors contribute to vascular inflammation in age-related macular degeneration, diabetic retinopathy, and glaucoma. We highlight the importance of mouse models in studying the underlying mechanisms and possible treatments for these diseases. We conclude that data support vascular inflammation playing a central if not primary role in retinal degenerative diseases, and this association should be a focus of future research.

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