Recoding the metagenome: microbiome engineering in situ.
Curr Opin Microbiol 2019 Oct 14; 50:28-34.
GM126893,NS105539,AI142733,AR075174,AR073562,National Science Foundation (1853071), the American Cancer Society, Leo Foundation, Denmark and Mark Foundation
Synthetic biology has enabled a new generation of tools for engineering the microbiome, including targeted antibiotics, protein delivery, living biosensors and diagnostics, and metabolic factories. Here, we discuss opportunities and limitations in microbiome engineering, focusing on a new generation of tools for in situ genetic modification of a microbiome that hold particular promise in circumventing these limitations.
Whitfill, Travis and Oh, Julia, "Recoding the metagenome: microbiome engineering in situ." (2019). Faculty Research 2019. 224.