Title

Recoding the metagenome: microbiome engineering in situ.

Document Type

Article

Publication Date

10-14-2019

Keywords

JGM

JAX Source

Curr Opin Microbiol 2019 Oct 14; 50:28-34.

PMID

31622928

DOI

https://doi.org/10.1016/j.mib.2019.09.005

Grant

GM126893,NS105539,AI142733,AR075174,AR073562,National Science Foundation (1853071), the American Cancer Society, Leo Foundation, Denmark and Mark Foundation

Abstract

Synthetic biology has enabled a new generation of tools for engineering the microbiome, including targeted antibiotics, protein delivery, living biosensors and diagnostics, and metabolic factories. Here, we discuss opportunities and limitations in microbiome engineering, focusing on a new generation of tools for in situ genetic modification of a microbiome that hold particular promise in circumventing these limitations.

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