Document Type

Article

Publication Date

1-15-2019

Keywords

JGM

JAX Source

NPJ Precis Oncol 2019 Jan 15; 3:2

PMID

30675517

DOI

https://doi.org/10.1038/s41698-018-0073-y

Abstract

Cancer genomic data is continually growing in complexity, necessitating improved methods for data capture and analysis. Tumors often contain multiple therapeutically relevant alterations, and co-occurring alterations may have a different influence on therapeutic response compared to if those alterations were present alone. One clinically important example of this is the existence of a resistance conferring alteration in combination with a therapeutic sensitizing mutation. The JAX Clinical Knowledgebase (JAX-CKB) (https://ckb.jax.org/) has incorporated the concept of the complex molecular profile, which enables association of therapeutic efficacy data with multiple genomic alterations simultaneously. This provides a mechanism for rapid and accurate assessment of complex cancer-related data, potentially aiding in streamlined clinical decision making. Using the JAX-CKB, we demonstrate the utility of associating data with complex profiles comprising ALK fusions with another variant, which have differing impacts on sensitivity to various ALK inhibitors depending on context.

Comments

The authors would like to thank Daniel Durkin, Asha Thadikemalla, Anuradha Lakshminarayana, Vinita Sinha, and Francisco Castellanos for their work on the JAX Clinical Knowledgebase.

This open access article is licensed under a Creative Commons Attribution 4.0 International License

Share

COinS