Front Immunol 2019 Jan 31; 10:99
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to the islets and extravasate through the islet vasculature. Understanding the cues that lead to T cell entry into inflamed islets is important because diagnosed T1D patients already have established immune infiltration of their islets. Here we show that CD11c
Sandor, Adam M; Lindsay, Robin S; Dyjack, Nathan; Whitesell, Jennifer C; Rios, Cydney; Bradley, Brenda J; Haskins, Kathryn; Serreze, David V.; Geurts, Aron M; Chen, Yi-Guang; Seibold, Max A; Jacobelli, Jordan; and Friedman, Rachel S, "CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes." (2019). Faculty Research 2019. 38.