Document Type

Article

Publication Date

3-4-2019

Keywords

JMG

JAX Source

NPJ Regen Med 2019 Mar 4; 4:5

PMID

30854227

DOI

https://doi.org/10.1038/s41536-019-0067-6

Grant

Australia Fellowship 546133, Stem Cells Australia SR1100102

Abstract

Clinical variation in patient responses to myocardial infarction (MI) has been difficult to model in laboratory animals. To assess the genetic basis of variation in outcomes after heart attack, we characterized responses to acute MI in the Collaborative Cross (CC), a multi-parental panel of genetically diverse mouse strains. Striking differences in post-MI functional, morphological, and myocardial scar features were detected across 32 CC founder and recombinant inbred strains. Transcriptomic analyses revealed a plausible link between increased intrinsic cardiac oxidative phosphorylation levels and MI-induced heart failure. The emergence of significant quantitative trait loci for several post-MI traits indicates that utilizing CC strains is a valid approach for gene network discovery in cardiovascular disease, enabling more accurate clinical risk assessment and prediction.

Comments

This open access article is licensed under a Creative Commons Attribution 4.0 International License

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