Document Type

Article

Publication Date

1-1-2019

Keywords

JMG

JAX Source

Database (Oxford) 2019 Jan 1;2019:baz036

PMID

30888410

DOI

https://doi.org/10.1093/database/baz036

Grant

CA034196,OD020351,AA18776

Abstract

Genomic data interpretation often requires analyses that move from a gene-by-gene focus to a focus on sets of genes that are associated with biological phenomena such as molecular processes, phenotypes, diseases, drug interactions or environmental conditions. Unique challenges exist in the curation of gene sets beyond the challenges in curation of individual genes. Here we highlight a literature curation workflow whereby gene sets are curated from peer-reviewed published data into GeneWeaver (GW), a data repository and analysis platform. We describe the system features that allow for a flexible yet precise curation procedure. We illustrate the value of curation by gene sets through analysis of independently curated sets that relate to the integrated stress response, showing that sets curated from independent sources all share significant Jaccard similarity. A suite of reproducible analysis tools is provided in GW as services to carry out interactive functional investigation of user-submitted gene sets within the context of over 150 000 gene sets constructed from publicly available resources and published gene lists. A curation interface supports the ability of users to design and maintain curation workflows of gene sets, including assigning, reviewing and releasing gene sets within a curation project context.

Comments

The authors would like to thank Robert Burgess, Emily Spaulding and Beena Kadhakhuza for their suggestions and comments toward this work.

Open access under the terms of the Creative Commons Attribution License

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