Document Type
Article
Publication Date
4-12-2019
Keywords
JMG
JAX Source
PLoS One 2019 Apr 12; 14($):e0214523
PMID
30978202
DOI
https://doi.org/10.1371/journal.pone.0214523
Grant
AG038070,AA018776
Abstract
Understanding the biological mechanisms behind aging, lifespan and healthspan is becoming increasingly important as the proportion of the world's population over the age of 65 grows, along with the cost and complexity of their care. BigData oriented approaches and analysis methods enable current and future bio-gerontologists to synthesize, distill and interpret vast, heterogeneous data from functional genomics studies of aging. GeneWeaver is an analysis system for integration of data that allows investigators to store, search, and analyze immense amounts of data including user-submitted experimental data, data from primary publications, and data in other databases. Aging related genome-wide gene sets from primary publications were curated into this system in concert with data from other model-organism and aging-specific databases, and applied to several questions in genrontology using. For example, we identified Cd63 as a frequently represented gene among aging-related genome-wide results. To evaluate the role of Cd63 in aging, we performed RNAi knockdown of the C. elegans ortholog, tsp-7, demonstrating that this manipulation is capable of extending lifespan. The tools in GeneWeaver enable aging researchers to make new discoveries into the associations between the genes, normal biological processes, and diseases that affect aging, healthspan, and lifespan.
Recommended Citation
Bubier, Jason A.; Sutphin, George L; Reynolds, Timothy J; Korstanje, Ron; Fuksman-Kumpa, Axis; Baker, Erich J; Langston, Michael A; and Chesler, Elissa J, "Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species." (2019). Faculty Research 2019. 93.
https://mouseion.jax.org/stfb2019/93
Comments
Open access under Creative Commons Attribution (CC BY) license (Creative Commons Attribution 4.0 International License).