Title

Doomed from the TERT? A Two-Stage Model of Tumorigenesis in IDH-Wild-Type Glioblastoma.

Document Type

Article

Publication Date

4-15-2019

Keywords

JGM

JAX Source

Cancer Cell 2019 Apr 15; 35(4):542-544

PMID

30991024

DOI

https://doi.org/10.1016/j.ccell.2019.03.009

Abstract

Using longitudinal molecular profiling, Körber et al. propose in this issue of Cancer Cell that IDH-wild-type glioblastomas initiate years pre-diagnosis with chromosome-level alterations that drive cell proliferation but require survival-promoting mutations, commonly in the TERT promoter, to form a detectable tumor. Multiple subclones drive disease progression, creating a therapeutic challenge.

Share

COinS