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Submissions from 2020

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The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma., Sophia Adamia, Ivane Abiatari, Samir Amin, Mariateresa Fulciniti, Stephane Minvielle, Cheng Li, Philippe Moreau, Herve Avet-Loiseau, Nikhil C Munshi, and Kenneth C Anderson

Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in, Mark D Adams, Fernando Pasteran, German M Traglia, Jasmine Martinez, Fanny Huang, Christine Liu, Jennifer S Fernandez, Carolina Lopez, Lisandro J Gonzalez, Ezequiel Albornoz, Alejandra Corso, Alejandro J Vila, Robert A Bonomo, and Maria Soledad Ramirez

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Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine., Zeeshan Ahmed, Khalid Mohamed, Saman Zeeshan, and XinQi Dong

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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer., Kadir C Akdemir, Victoria T Le, Sahaana Chandran, Yilong Li, Roel G W Verhaak, Rameen Beroukhim, Peter J Campbell, Lynda Chin, Jesse R Dixon, P Andrew Futreal, PCAWG Structural Variation Working Groug, and PCAWG Consortium

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Comparative Molecular Life History of Spontaneous Canine and Human Gliomas., Samirkumar B Amin, Kevin J Anderson, C Elizabeth Boudreau, Emmanuel Martinez-Ledesma, Emre Kocakavuk, Kevin C Johnson, Floris P Barthel, Frederick S Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barter, Ching C Lau, Chew Yee Ngan, Margaret Chapman, Jennifer W Koehler, James P Long, Andrew D Miller, C Ryan Miller, Brian F Porter, Daniel R Rissi, Christina Mazcko, Amy K LeBlanc, Peter J Dickinson, Rebecca A Packer, Amanda R Taylor, John H Rossmeisl, Kevin D Woolard, Amy B Heimberger, Jonathan M Levine, and Roel G W Verhaak

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Molecular and clonal evolution in recurrent metastatic gliosarcoma., Kevin J Anderson, Aaron C Tan, Jonathon Parkinson, Michael Back, Marina Kastelan, Allison Newey, Janice Brewer, Helen Wheeler, Amanda L Hudson, Samirkumar B Amin, Kevin C Johnson, Floris P Barthel, Roel G W Verhaak, and Mustafa Khasraw

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Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data., Haitham Ashoor, Xiaowen Chen, Wojciech Rosikiewicz, Jiahui Wang, Albert Cheng, Ping Wang, Yijun Ruan, and Sheng Li

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Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B., Ana Rita Batista, Oliver D King, Christopher P Reardon, Crystal Davis, Shankaracharya, Vivek M. Philip, Heather Gray-Edwards, Neil Aronin, Cathleen Lutz, John Landers, and Miguel Sena-Esteves

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Know Your Model: How essential is that essential gene?, Susan M. Bello, Melissa L. Berry, and Cynthia L Smith

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Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma., Noah E Berlow, Catherine S Grasso, Michael J Quist, Mingshan Cheng, Regina Gandour-Edwards, Brian S Hernandez, Joel E Michalek, Christopher Ryan, Paul Spellman, Ranadip Pal, Lynn S Million, Mark Renneker, and Charles Keller

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Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data., Molly A. Bogue, Vivek M. Philip, David O Walton, Stephen C. Grubb, Matthew H Dunn, Georgi Kolishovski, Jake Emerson, Gaurab Mukherjee, Timothy M Stearns, Hao He, Vinita Sinha, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, and Elissa J Chesler

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Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice., Jane Branca, Benjamin E. Low, Ruth L. Saxl, Jennifer K Sargent, Rosalinda A. Doty, Michael V. Wiles, Beth L Dumont, and Muneer G. Hasham

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A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice., Jason A. Bubier, Vivek M. Philip, Christopher Quince, James Campbell, Yanjiao Zhou, Tatiana Vishnivetskaya, Suman Duvvuru, Rachel Hageman Blair, Juliet Ndukum, Kevin D Donohue, Carmen M Foster, David J Mellert, George M. Weinstock, Cymbeline T Culiat, Bruce F O'Hara, Anthony V Palumbo, Mircea Podar, and Elissa J Chesler

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Human and mouse essentiality screens as a resource for disease gene discovery., Pilar Cacheiro, Violeta Muñoz-Fuentes, Stephen A. Murray, Mary E Dickinson, Maja Bucan, Lauryl M J Nutter, Kevin A Peterson, Hamed Haselimashhadi, Ann M Flenniken, Hugh Morgan, Henrik Westerberg, Tomasz Konopka, Chih-Wei Hsu, Audrey Christiansen, Denise G Lanza, Arthur L Beaudet, Jason D Heaney, Helmut Fuchs, Valerie Gailus-Durner, Tania Sorg, Jan Prochazka, Vendula Novosadova, Christopher J Lelliott, Hannah Wardle-Jones, Sara Wells, Lydia Teboul, Heather Cater, Michelle Stewart, Tertius Hough, Wolfgang Wurst, Radislav Sedlacek, David J Adams, John R Seavitt, Glauco Tocchini-Valentini, Fabio Mammano, Robert E Braun, Colin McKerlie, Yann Herault, Martin Hrabě de Angelis, Ann-Marie Mallon, K C Kent Lloyd, Steve D M Brown, Helen Parkinson, Terrence F Meehan, Damian Smedley, Genomics England Research Consortium, and International Mouse Phenotyping Consortium

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Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells., Zhigang Cai, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J Kotzin, Martin Carroll, Gerald Wertheim, Adam Williams, Sarath Chandra Janga, Chi Zhang, Jorge Henao-Mejia, and Reuben Kapur

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Methods for comparative ChIA-PET and Hi-C data analysis., Dan Capurso, Zhonghui Tang, and Yijun Ruan

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Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes., Leigh Carmody, Hannah Blau, Daniel Danis, Xingman A Zhang, Jean-Philippe Gourdine, Nicole Vasilevsky, Peter Krawitz, Miles D Thompson, and Peter N Robinson

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Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype-like Cluster., Yanfei Chen, Masako Nakanishi, Eddy J Bautista, Veneta Qendro, Erica Sodergren, Daniel W Rosenberg, and George M. Weinstock

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Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers., Sung-Yup Cho, Yumi Oh, Eui Man Jeong, Sanghui Park, Dakeun Lee, Xiaorui Wang, Qiqi Zeng, Hongyu Qin, Fang Hu, Hui Gong, Xi Liu, Guanjun Zhang, Deukchae Na, Jieun Lee, Jeesoo Chae, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, Jong-Il Kim, Hansoo Park, Chengsheng Zhang, Han-Kwang Yang, and Charles Lee

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An Improved Phenotype-Driven Tool for Rare Mendelian Variant Prioritization: Benchmarking Exomiser on Real Patient Whole-Exome Data., Valentina Cipriani, Nikolas Pontikos, Gavin Arno, Panagiotis I Sergouniotis, Eva Lenassi, Penpitcha Thawong, Daniel Danis, Michel Michaelides, Andrew R Webster, Anthony T Moore, Peter N Robinson, Julius O B Jacobsen, and Damian Smedley

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Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss., Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F Hyde, Lisa Stone, Patsy M. Nishina, Mark P. Krebs, and Juergen K. Naggert

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Disruption in murine Eml1 perturbs retinal lamination during early development., Gayle B. Collin, J Won, Mark P. Krebs, W J Hicks, Jeremy R. Charette, Juergen K. Naggert, and Patsy M. Nishina

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What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?, Bella Luna Colombini-Ishikiriama, Thiago Jose Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha de Oliveira, Vanessa Soares Lara, Andrew S Greene, and Carlos Ferreira Santos

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Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable., Chunhua Dai, John T Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle Dean, Nripesh Prasad, Shawn E Levy, Dale L Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C Powers

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Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis., Udita Datta, Sarah E Schoenrock, Jason A. Bubier, Molly A. Bogue, James D Jentsch, Ryan W Logan, Lisa M Tarantino, and Elissa J Chesler

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Stimulus Complexity and Mouse Strain Drive Escalation of Operant Sensation Seeking Within and Across Sessions in C57BL/6J and DBA/2J Mice., Price E. Dickson and Guy Mittleman

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Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using d-Alanine Auxotrophy., David Dodds, Jeffrey L Bose, Ming-De Deng, Gilles R Dubé, Trudy H Grossman, Alaina Kaiser, Kashmira Kulkarni, Roger Leger, Sara Mootien-Boyd, Azim Munivar, Julia Oh, Matthew Pestrak, Komal Rajpura, Alexander P Tikhonov, Traci Turecek, and Travis Whitfill

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Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study., Kaspar Draaisma, Aikaterini Chatzipli, Martin Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Slávka Lukacova, Giuseppe Lombardi, Sieger Leenstra, Monique Hanse, Ruth Fleischeuer, Colin Watts, Joseph McAbee, Nicos Angelopoulos, Thierry Gorlia, Vassilis Golfinopoulos, Johan M Kros, Roel G W Verhaak, Vincent Bours, Martin J van den Bent, Ultan McDermott, Pierre A Robe, and Pim J French

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CRISPR artificial splicing factors., Menghan Du, Nathaniel L. Jillette, Jacqueline Jufen Zhu, Sheng Li, and Albert Wu Cheng

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Evolution: Is Recombination Rate Variation Adaptive?, Beth L Dumont

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Cancer Stem Cells: Notes for Authors., Connie J Eaves and Martin Pera

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Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and γ-ray-induced tumors., E F Edmondson, Daniel M Gatti, F A Ray, E L Garcia, C M Fallgren, D A Kamstock, and M M Weil

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Comprehensive overview of COVID-19 clinical trials., Kiran Ejaz, Tanveer Kauser, and Amnah Siddiqa

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Metagenomic growth rate inferences of strains in situ., Akintunde Emiola, Wei Zhou, and Julia Oh

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Teasing the Immune System to Repair the Heart., Jonathan A Epstein, Nadia Rosenthal, and Arthur M Feldman

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Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats., Eric C Exner, Aron M Geurts, Brian R Hoffmann, Marc Casati, Timothy Stodola, Nikita R Dsouza, Michael Zimmermann, Julian H Lombard, and Andrew S Greene

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The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137, Bardees M Foda, Ashley E Ciecko, David V. Serreze, William M Ridgway, Aron M Geurts, and Yi-Guang Chen

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Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice., Elvira Forte, Daniel A Skelly, Mandy Chen, Sandra Daigle, Kaesi A Morelli, Olivia Hon, Vivek M. Philip, Mauro W Costa, Nadia Rosenthal, and Milena B Furtado

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Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy., Peiheng Gan, Michaela Patterson, Hirofumi Watanabe, Kristy Wang, Reilly A Edmonds, Laura G Reinholdt, and Henry M Sucov

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Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites., Elie Hammam, Guruprasad Ananda, Ameya Sinha, Christine Scheidig-Benatar, Mylene Bohec, Peter R Preiser, Peter C Dedon, Artur Scherf, and Shruthi S Vembar

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The XY body: an attractive chromatin domain., Mary Ann Handel

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circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan., Shahnaz Haque, Ryan M Ames, Karen Moore, Luke C Pilling, Luanne L. Peters, Stefania Bandinelli, Luigi Ferrucci, and Lorna W Harries

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Soft windowing application to improve analysis of high-throughput phenotyping data., Hamed Haselimashhadi, Jeremy C Mason, Violeta Munoz-Fuentes, Federico López-Gómez, Kolawole Babalola, Elif F Acar, Vivek Kumar, Jacqui White, Ann M Flenniken, Ruairidh King, Ewan Straiton, John Richard Seavitt, Angelina Gaspero, Arturo Garza, Audrey E Christianson, Chih-Wei Hsu, Corey L Reynolds, Denise G Lanza, Isabel Lorenzo, Jennie R Green, Juan J Gallegos, Ritu Bohat, Rodney C Samaco, Surabi Veeraragavan, Jong Kyoung Kim, Gregor Miller, Helmult Fuchs, Lillian Garrett, Lore Becker, Yeon Kyung Kang, David Clary, Soo Young Cho, Masaru Tamura, Nobuhiko Tanaka, Kyung Dong Soo, Alexandr Bezginov, Ghina Bou About, Marie-France Champy, Laurent Vasseur, Sophie Leblanc, Hamid Meziane, Mohammed Selloum, Patrick T Reilly, Nadine Spielmann, Holger Maier, Valerie Gailus-Durner, Tania Sorg, Masuya Hiroshi, Obata Yuichi, Jason D Heaney, Mary E Dickinson, Wurst Wolfgang, Glauco P Tocchini-Valentini, Kevin C Kent Lloyd, Colin McKerlie, Je Kyung Seong, Herault Yann, Martin Hrabé de Angelis, Steve D M Brown, Damian Smedley, Paul Flicek, Ann-Marie Mallon, Helen Parkinson, and Terrence F Meehan

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The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities., Eleanor Herbert, Michelle Stewart, Marie Hutchison, Ann M Flenniken, Dawei Qu, Lauryl M J Nutter, Colin McKerlie, Liane Hobson, Brenda Kick, Bonnie L. Lyons, Jean-Paul Wiegand, Rosalinda A. Doty, Juan Antonio Aguilar-Pimentel, Martin Hrabe de Angelis, Mary Dickinson, John Seavitt, Jacqueline K White, Cheryl L Scudamore, and Sara Wells

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Low SATB1 Expression Promotes IL-5 and IL-9 Expression in Sézary Syndrome., Alberto Herrera, Simon Fredholm, Anthony Cheng, Eleni P Mimitou, Angelina Seffens, Michal Bar-Natan, Amy Sun, Jo-Ann Latkowski, Andreas Willerslew-Olsen, Terkild B Buus, Maria Gluud, Thorbjørn Krejsgaard, Sara Torres-Rusillo, Charlotte Menné Bonefeld, Anders Woetmann, Carsten Geisler, Larisa J Geskin, Zhengqing Ouyang, Peter Smibert, Niels Ødum, and Sergei B Koralov

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Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells., Yoshiki Higashijima, Yusuke Matsui, Teppei Shimamura, Ryo Nakaki, Nao Nagai, Shuichi Tsutsumi, Yohei Abe, Verena M Link, Mizuko Osaka, Masayuki Yoshida, Ryo Watanabe, Toshihiro Tanaka, Akashi Taguchi, Mai Miura, Xiaoan Ruan, Guoliang Li, Tsuyoshi Inoue, Masaomi Nangaku, Hiroshi Kimura, Tetsushi Furukawa, Hiroyuki Aburatani, Youichiro Wada, Yijun Ruan, Christopher K Glass, and Yasuharu Kanki

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Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells., Insoo Hyun, Megan Munsie, Martin F Pera, Nicolas C Rivron, and Janet Rossant

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Integrating image caption information into biomedical document classification in support of biocuration., Xiangying Jiang, Pengyuan Li, James A. Kadin, Judith A. Blake, Martin Ringwald, and Hagit Shatkay

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Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle., Ataur Katebi, Vivek Kohar, and Mingyang Lu

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Decoy exosomes provide protection against bacterial toxins., Matthew D Keller, Krystal L Ching, Feng-Xia Liang, Avantika Dhabaria, Kayan Tam, Beatrix M Ueberheide, Derya Unutmaz, Victor J Torres, and Ken Cadwell

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Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation., Eraj Shafiq Khokhar, Sneha Borikar, Elizabeth Eudy, Timothy M Stearns, Kira Young, and Jennifer J. Trowbridge

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Automated generation of gene summaries at the Alliance of Genome Resources., Ranjana Kishore, Valerio Arnaboldi, Ceri E Van Slyke, Juancarlos Chan, Robert S Nash, Jose M Urbano, Mary E. Dolan, Stacia R Engel, Mary Shimoyama, Paul W Sternberg, and The Alliance Of Genome Resources

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A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes., Heike Kollmus, Helmut Fuchs, Christoph Lengger, Hamed Haselimashhadi, Molly A. Bogue, Manuela A Östereicher, Marion Horsch, Thure Adler, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Johannes Beckers, Julia Calzada-Wack, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Tanja Klein-Rodewald, Holger Maier, Philipp Mayer-Kuckuk, Gregor Miller, Kristin Moreth, Frauke Neff, Birgit Rathkolb, Ildikó Rácz, Jan Rozman, Nadine Spielmann, Irina Treise, Dirk Busch, Jochen Graw, Thomas Klopstock, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Jeremy Mason, Arturo Torres, Mouse Phenome Database Team, Rudi Balling, Terry Mehaan, Valerie Gailus-Durner, Klaus Schughart, and Martin Hrabě de Angelis

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Systems biology of ferroptosis: A modeling approach., Anna Konstorum, Lia Tesfay, Bibbin T Paul, Frank M Torti, Reinhard Laubenbacher, and Suzy V Torti

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Long non-coding RNAs in immune regulation and their potential as therapeutic targets., Dinesh Babu Uthaya Kumar and Adam Williams

From GWAS Association to Function: Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model., Feria A Ladha, Michael L. Stitzel, and J Travis Hinson

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Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal., Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L. Baker, Tracy C. McGarr, Christine A Wells, and Martin Pera

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miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells., Clarice X Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A Flavell, Jorge Henao-Mejia, and Herbert Strobl

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GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells., thomas lisse, Manju Sharma, Neda Vishlaghi, Sri Ramulu N Pullagura, and Robert E Braun

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The Deep Genome Project., K C Kent Lloyd, David J Adams, Gareth Baynam, Arthur L Beaudet, Fatima Bosch, Kym M Boycott, Robert E Braun, Mark Caulfield, Ronald Cohn, Mary E Dickinson, Michael S Dobbie, Ann M Flenniken, Paul Flicek, Sanjeev Galande, Xiang Gao, Anne Grobler, Jason D Heaney, Yann Herault, Martin Hrabě de Angelis, James R Lupski, Stanislas Lyonnet, Ann-Marie Mallon, Fabio Mammano, Calum A MacRae, Roderick McInnes, Colin McKerlie, Terrence F Meehan, Stephen A Murray, Lauryl M J Nutter, Yuichi Obata, Helen Parkinson, Michael S Pepper, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Damian Smedley, Glauco Tocchini-Valentini, David Valle, Chi-Kuang Leo Wang, Sara Wells, Jacqueline K White, Wolfgang Wurst, Ying Xu, and Steve D M Brown

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LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding., Huacheng Luo, Qin Yu, Yang Liu, Ming Tang, Mingwei Liang, Dingpeng Zhang, Tsan Sam Xiao, Lizi Wu, Ming Tan, Yijun Ruan, Jörg Bungert, and Jianrong Lu

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Realizing the gains and losses in C9ORF72 ALS/FTD., Cathleen Lutz

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COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice., Cathleen Lutz, Leigh Maher, Charles Lee, and Wonyoung Kang

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Sexual-dimorphism in human immune system aging., Eladio J Márquez, Cheng-Han Chung, Radu Marches, Robert J Rossi, Djamel Nehar-Belaid, Alper Eroglu, David J Mellert, George A Kuchel, Jacques Banchereau, and Duygu Ucar

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The lethal sex gap: COVID-19., Eladio J Márquez, Jennifer J. Trowbridge, George A Kuchel, Jacques Banchereau, and Duygu Ucar

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Overlapping spectrums: The clinicogenetic commonalities between Charcot-Marie-Tooth and other neurodegenerative diseases., Paige B Martin, Amy N Hicks, Sarah E Holbrook, and Gregory A. Cox

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Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology., Nikhil Milind, Christoph Preuss, Annat Haber, Guruprasad Ananda, Shubhabrata Mukherjee, Cai John, Sarah Shapley, Benjamin A Logsdon, Paul K Crane, and Gregory W. Carter

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Gene therapies for axonal neuropathies: Available strategies, successes to date, and what to target next., Kathryn H Morelli, Courtney L Hatton, Scott Q Harper, and Robert W. Burgess

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The acquisition of positional information across the radial axis of the cochlea., Vidhya Munnamalai and Donna M Fekete

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Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways., Xiang Nan, Jiang Wang, Hao Cheng, Zheng Yin, Jianting Sheng, Bensheng Qiu, Ching C Lau, Jason T Yustein, Hong Zhao, and Stephen T C Wong

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A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities., Ravi S Narayan, Piet Molenaar, Jian Teng, Fleur M G Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C Lecca, Kristiaan J Lenos, Sjors G J G In 't Veld, Wessel van Wieringen, Frederick F Lang, Erik Sulman, Roel G W Verhaak, Brigitta G Baumert, Lucas J A Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A Tannous, Tom Wurdinger, Jan Koster, and Bart A Westerman

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Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development., Chew Yee Ngan, Chee-Hong Wong, Harianto Tjong, Wenbo Wang, Rachel L Goldfeder, Cindy Choi, Hao He, Liang Gong, Junyan Lin, Barbara Urban, Julianna Chow, Meihong Li, Joanne Lim, Vivek M. Philip, Stephen A. Murray, Haoyi Wang, and Chia-Lin Wei

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Molecular profiling of CNS tumors for the treatment and management of disease., Qian Nie, Meng-Chang Hsiao, Harshpreet Chandok, Shannon Rowe, Matthew Prego, Bridgette Meyers, Gregory Omerza, Andrew N Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Jens Rueter, and Honey V Reddi

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Molecular profiling of gynecologic cancers for treatment and management of disease - demonstrating clinical significance using the AMP/ASCO/CAP guidelines for interpretation and reporting of somatic variants., Qian Nie, Gregory Omerza, Harshpreet Chandok, Matthew Prego, Meng-Chang Hsiao, Bridgette Meyers, Andrew N Hesse, Jasmina Uvalic, Melissa Soucy, Daniel Bergeron, Michael Peracchio, Shelbi Burns, Kevin Kelly, Shannon Rowe, Jens Rueter, and Honey V Reddi

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An intact C-terminal end of albumin is required for its long half-life in humans., Jeannette Nilsen, Esben Trabjerg, Algirdas Grevys, Claudia Azevedo, Stephen O Brennan, Maria Stensland, John J Wilson, Kine Marita Knudsen Sand, Malin Bern, Bjørn Dalhus, Derry C. Roopenian, Inger Sandlie, Kasper Dyrberg Rand, and Jan Terje Andersen

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Treating Cancer as an Invasive Species., Javad Noorbakhsh, Zi-Ming Zhao, James C Russell, and Jeffrey H Chuang

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MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics., Zhiqiang Pang, Jasmine Chong, Shuzhao Li, and Jianguo Xia

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parSMURF, a high-performance computing tool for the genome-wide detection of pathogenic variants., Alessandro Petrini, Marco Mesiti, Max Schubach, Marco Frasca, Daniel Danis, Matteo Re, Giuliano Grossi, Luca Cappelletti, Tiziana Castrignanò, Peter N Robinson, and Giorgio Valentini

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The contribution of microRNA-mediated regulation to short- and long-term gene expression predictability., Russell Posner and Reinhard Laubenbacher

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Toward Modeling Context-Specific EMT Regulatory Networks Using Temporal Single Cell RNA-Seq Data., Daniel Ramirez, Vivek Kohar, and Mingyang Lu

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Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice., Sambra D Redick, Linda Leehy, Ann R Rittenhouse, David M Blodgett, Alan G Derr, Alper Kucukural, Manuel G Garber, Leonard D. Shultz, Dale L Greiner, Jennifer P Wang, David M Harlan, Rita Bortell, and Agata Jurczyk

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Differential Effects of Rapamycin on Glucose Metabolism in Nine Inbred Strains., Peter C. Reifsnyder, Austen Te, and David E Harrison

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Improving Characterization of Understudied Human Microbiomes Using Targeted Phylogenetics., Bruce A Rosa, Kathie Mihindukulasuriya, Kymberlie Hallsworth-Pepin, Aye Wollam, John Martin, Caroline Snowden, William Michael Dunne, George M. Weinstock, C A Burnham, and Makedonka Mitreva

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TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis., Wojciech Rosikiewicz, Xiaowen Chen, Pilar M Dominguez, Hussein Ghamlouch, Said Aoufouchi, Olivier A Bernard, Ari Melnick, and Sheng Li

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PATHBIO: an international training program for precision mouse phenotyping., Jesus Ruberte, Paul N Schofield, Cord Brakebusch, Peter Vogel, Yann Herault, Guillem Gracia, Colin McKerlie, Martin Hrabĕ de Angelis, Michael Hagn, and John P Sundberg

Mutation Yield of a Custom 212-Gene Next-Generation Sequencing Panel for Solid Tumors: Clinical Experience of the First 260 Cases Tested Using the JAX ActionSeq™ Assay., Pavalan Selvam, Meng-Chang Hsiao, Gregory Omerza, Daniel Bergeron, Shannon Rowe, Jasmina Uvalic, Melissa Soucy, Michael Peracchio, Shelbi Burns, Bridgette Meyers, Matthew Prego, Qian Nie, Guruprasad Ananda, Harshpreet Chandok, Kevin Kelly, Andrew N Hesse, and Honey V Reddi

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The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species., Kent A Shefchek, Nomi L Harris, Michael Gargano, Nicolas Matentzoglu, Deepak Unni, Matthew Brush, Daniel Keith, Tom Conlin, Nicole Vasilevsky, Xingmin Aaron Zhang, James P Balhoff, Larry Babb, Susan M. Bello, Hannah Blau, Yvonne Bradford, Seth Carbon, Leigh Carmody, Lauren E Chan, Valentina Cipriani, Alayne Cuzick, Maria D Rocca, Nathan Dunn, Shahim Essaid, Petra Fey, Chris Grove, Jean-Phillipe Gourdine, Ada Hamosh, Midori Harris, Ingo Helbig, Maureen Hoatlin, Marcin Joachimiak, Simon Jupp, Kenneth B Lett, Suzanna E Lewis, Craig McNamara, Zoë M Pendlington, Clare Pilgrim, Tim Putman, Vida Ravanmehr, Justin Reese, Erin Riggs, Sofia Robb, Paola Roncaglia, James Seager, Erik Segerdell, Morgan Similuk, Andrea L Storm, Courtney Thaxon, Anne Thessen, Julius O B Jacobsen, Julie A McMurry, Tudor Groza, Sebastian Köhler, Damian Smedley, Peter N Robinson, Christopher J Mungall, Melissa A Haendel, Monica C Munoz-Torres, and David Osumi-Sutherland

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GXD's RNA-Seq and Microarray Experiment Search: using curated metadata to reliably find mouse expression studies of interest., Constance M. Smith, James W Godwin, Richard M. Baldarelli, Jonathan S Beal, Olin Blodgett, Sharon C Giannatto, Joel E Richardson, and Martin Ringwald

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Molecular Biology and Evolution of Cancer: From Discovery to Action., Jason A Somarelli, Heather Gardner, Vincent L Cannataro, Ella F Gunady, Amy M Boddy, Norman A Johnson, Jeffrey Nicholas Fisk, Stephen G Gaffney, Jeffrey Chuang, Sheng Li, Francesca D Ciccarelli, Anna R Panchenko, Kate Megquier, Sudhir Kumar, Alex Dornburg, James DeGregori, and Jeffrey P Townsend

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Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients., Daniel Spakowicz, Shaoke Lou, Brian Barron, Jose L Gomez, Tianxiao Li, Qing Liu, Nicole Grant, Xiting Yan, Rebecca Hoyd, George M. Weinstock, Geoffrey L Chupp, and Mark Gerstein

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A Universal, Genomewide GuideFinder for CRISPR/Cas9 Targeting in Microbial Genomes., Michelle Spoto, Changhui Guan, Elizabeth Fleming, and Julia Oh

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HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots., Catrina Spruce, Sibongakonke Dlamini, Guruprasad Ananda, Naomi Bronkema, Hui Tian, Kenneth Paigen, Gregory W. Carter, and Christopher L. Baker

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Innovations, challenges, and minimal information for standardization of humanized mice., Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl-Dimiter Bissig, Brian Soper, Terrence Meeham, Li-Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb-Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol J Bult, and Leonard D. Shultz

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GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone., Joonho Suh, Na-Kyung Kim, Seung-Hoon Lee, Je-Hyun Eom, Youngkyun Lee, Joo-Cheol Park, Kyung Mi Woo, Jeong-Hwa Baek, Jung-Eun Kim, Hyun-Mo Ryoo, Se-Jin Lee, and Yun-Sil Lee

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Improving preclinical to clinical translation in Alzheimer's disease research., Stacey J Sukoff Rizzo, Andi Masters, Kristen D. Onos, Sara Quinney, Michael Sasner, Adrian Oblak, Bruce T Lamb, Paul R Territo, and MODEL-AD Consortium

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Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy., Jeremy M Sullivan, William W Motley, Janel O Johnson, William H Aisenberg, Katherine L Marshall, Katy Es Barwick, Lingling Kong, Jennifer S Huh, Pamela C Saavedra-Rivera, Meriel M McEntagart, Marie-Helene Marion, Lucy A Hicklin, Hamid Modarres, Emma L Baple, Mohamed H Farah, Aamir Zuberi, Cathleen Lutz, Rachelle Gaudet, Bryan J Traynor, Andrew H Crosby, and Charlotte J Sumner

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TBX1 is required for normal stria vascularis and semicircular canal development., Cong Tian and Kenneth R. Johnson

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Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice., James R Tribble, Jeffrey M. Harder, Pete A Williams, and Simon W M John

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A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei., Jaishree Tripathi, Charis-Patricia Segeritz, Gareth Griffiths, Wendy Bushell, Ludovic Vallier, William C Skarnes, Maria M Mota, and Oliver Billker

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Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization., Paweł Trzaskoma, Błażej Ruszczycki, Byoungkoo Lee, Katarzyna K Pels, Katarzyna Krawczyk, Grzegorz Bokota, Andrzej A Szczepankiewicz, Jesse Aaron, Agnieszka Walczak, Małgorzata A Śliwińska, Adriana Magalska, Michal Kadlof, Artur Wolny, Zofia Parteka, Sebastian Arabasz, Magdalena Kiss-Arabasz, Dariusz Plewczyński, Yijun Ruan, and Grzegorz M Wilczyński