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Submissions from 2020

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The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma., Sophia Adamia, Ivane Abiatari, Samir Amin, Mariateresa Fulciniti, Stephane Minvielle, Cheng Li, Philippe Moreau, Herve Avet-Loiseau, Nikhil C Munshi, and Kenneth C Anderson

Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in, Mark D Adams, Fernando Pasteran, German M Traglia, Jasmine Martinez, Fanny Huang, Christine Liu, Jennifer S Fernandez, Carolina Lopez, Lisandro J Gonzalez, Ezequiel Albornoz, Alejandra Corso, Alejandro J Vila, Robert A Bonomo, and Maria Soledad Ramirez

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Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine., Zeeshan Ahmed, Khalid Mohamed, Saman Zeeshan, and XinQi Dong

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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer., Kadir C Akdemir, Victoria T Le, Sahaana Chandran, Yilong Li, Roel G W Verhaak, Rameen Beroukhim, Peter J Campbell, Lynda Chin, Jesse R Dixon, P Andrew Futreal, PCAWG Structural Variation Working Groug, and PCAWG Consortium

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Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure., Kadir C Akdemir, Victoria T Le, Justin M Kim, Sarah Killcoyne, Devin A King, Ya-Ping Lin, Yanyan Tian, Akira Inoue, Samirkumar B Amin, Frederick S Robinson, Manjunath Nimmakayalu, Rafael E Herrera, Erica J Lynn, Kin Chan, Sahil Seth, Leszek J Klimczak, Moritz Gerstung, Dmitry A Gordenin, John O'Brien, Lei Li, Yonathan Lissanu Deribe, Roel G W Verhaak, Peter J Campbell, Rebecca Fitzgerald, Ashby J Morrison, Jesse R Dixon, and P Andrew Futreal

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Comparative Molecular Life History of Spontaneous Canine and Human Gliomas., Samirkumar B Amin, Kevin J Anderson, C Elizabeth Boudreau, Emmanuel Martinez-Ledesma, Emre Kocakavuk, Kevin C Johnson, Floris P Barthel, Frederick S Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barter, Ching C Lau, Chew Yee Ngan, Margaret Chapman, Jennifer W Koehler, James P Long, Andrew D Miller, C Ryan Miller, Brian F Porter, Daniel R Rissi, Christina Mazcko, Amy K LeBlanc, Peter J Dickinson, Rebecca A Packer, Amanda R Taylor, John H Rossmeisl, Kevin D Woolard, Amy B Heimberger, Jonathan M Levine, and Roel G W Verhaak

The influence of uncertainty and uncertainty tolerance on attitudes and self-efficacy about genomic tumor testing., Eric C Anderson, Alexandra Hinton, Christine W Lary, Tania Strout, Andrey Antov, Emily A Edelman, Petra Helbig, Kate Reed, Jens Rueter, and Paul K J Han

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Molecular and clonal evolution in recurrent metastatic gliosarcoma., Kevin J Anderson, Aaron C Tan, Jonathon Parkinson, Michael Back, Marina Kastelan, Allison Newey, Janice Brewer, Helen Wheeler, Amanda L Hudson, Samirkumar B Amin, Kevin C Johnson, Floris P Barthel, Roel G W Verhaak, and Mustafa Khasraw

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Rapamycin rejuvenates oral health in aging mice., Jonathan Y An, Kristopher A Kerns, Andrew R Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, and Matt Kaeberlein

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Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data., Haitham Ashoor, Xiaowen Chen, Wojciech Rosikiewicz, Jiahui Wang, Albert Cheng, Ping Wang, Yijun Ruan, and Sheng Li

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A guide to writing systematic reviews of rare disease treatments to generate FAIR-compliant datasets: building a Treatabolome., Antonio Atalaia, Rachel Thompson, Alberto Corvo, Leigh Carmody, Davide Piscia, Leslie Matalonga, Alfons Macaya, Angela Lochmuller, Bertrand Fontaine, Birte Zurek, Carles Hernandez-Ferrer, Carola Rheinard, David Gómez-Andrés, Jean-François Desaphy, Katherine Schon, Katja Lohmann, Matthew J Jennings, Matthis Synofzik, Olaf Riess, Rabah Ben Yaou, Teresinha Evangelista, Thiloka Ratnaike, Virginie Bros-Facer, Gulcin Gumus, Rita Horvath, Patrick Chinnery, Steven Laurie, Holm Graessner, Peter N Robinson, Hanns Lochmuller, Sergi Beltran, and Gisèle Bonne

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Structural variant identification and characterization., Parithi Balachandran and Christine R Beck

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Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B., Ana Rita Batista, Oliver D King, Christopher P Reardon, Crystal Davis, Shankaracharya, Vivek M. Philip, Heather Gray-Edwards, Neil Aronin, Cathleen Lutz, John Landers, and Miguel Sena-Esteves

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Know Your Model: How essential is that essential gene?, Susan M. Bello, Melissa L. Berry, and Cynthia L Smith

Know Your Model: A knockout does not always make a null., Susan M. Bello, Michelle N Perry, and Cynthia Smith

Know Your Model: The role of sex in phenotype penetrance and severity., Susan M. Bello, Michelle N Perry, and Cynthia Smith

Know Your Model: When parental origin matters., Susan M. Bello, Michelle N Perry, and Cynthia Smith

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Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma., Noah E Berlow, Catherine S Grasso, Michael J Quist, Mingshan Cheng, Regina Gandour-Edwards, Brian S Hernandez, Joel E Michalek, Christopher Ryan, Paul Spellman, Ranadip Pal, Lynn S Million, Mark Renneker, and Charles Keller

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An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics., Malin Bern, Jeannette Nilsen, Mattia Ferrarese, Kine M K Sand, Torleif T Gjølberg, Heidrun E Lode, Robert J Davidson, Rodney M Camire, Espen S Bækkevold, Stian Foss, Algirdas Grevys, Bjørn Dalhus, John J Wilson, Lene S Høydahl, Gregory J. Christianson, Derry C. Roopenian, Tilman Schlothauer, Terje E Michaelsen, Morten C Moe, Silvia Lombardi, Mirko Pinotti, Inger Sandlie, Alessio Branchini, and Jan Terje Andersen

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The involvement of neuroimmune cells in adipose innervation., Magdalena Blaszkiewicz, Elizabeth Wood, Sigi Koizar, Jake Willows, Ryan Anderson, Yu-Hua Tseng, James W Godwin, and Kristy L Townsend

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Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data., Molly A. Bogue, Vivek M. Philip, David O Walton, Stephen C. Grubb, Matthew H Dunn, Georgi Kolishovski, Jake Emerson, Gaurab Mukherjee, Timothy M Stearns, Hao He, Vinita Sinha, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, and Elissa J Chesler

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Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells., Marion Bouvet, Olivier Claude, Maguelonne Roux, Daniel A Skelly, Nihar Masurkar, Nathalie Mougenot, Sophie Nadaud, Catherine Blanc, Clément Delacroix, Solenne Chardonnet, Cédric Pionneau, Claire Perret, Elisa Yaniz-Galende, Nadia Rosenthal, David-Alexandre Trégouët, Giovanna Marazzi, Jean-Sébastien Silvestre, David Sassoon, and Jean-Sébastien Hulot

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Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice., Jane Branca, Benjamin E. Low, Ruth L. Saxl, Jennifer K Sargent, Rosalinda A. Doty, Michael V. Wiles, Beth L Dumont, and Muneer G. Hasham

Evidence for a Novel Endometrioid Carcinogenic Sequence in the Fallopian Tube With Unique Beta-Catenin Expression., Jan Brouwer, Kyle C Strickland, Gang Ning, Cindy B Schmelkin, David L Kolin, Jonathan Hecht, Marisa R Nucci, Marian J Mourits, Wa Xian, and Christopher P Crum

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Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling, Heather Mary Brown, Stephen A. Murray, Hope Northrup, Kit Sing Au, and Lee A Niswander

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Sensitivity of comorbidity network analysis., Jason Cory Brunson, Thomas P Agresta, and Reinhard Laubenbacher

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Genetic variation regulates opioid-induced respiratory depression in mice., Jason A. Bubier, Hao He, Vivek M. Philip, Tyler A. Roy, Christian Monroy Hernandez, Rebecca Bernat, Kevin D Donohue, Bruce F O'Hara, and Elissa J Chesler

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Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis, Jason A. Bubier, Vivek M. Philip, Price E. Dickson, Guy Mittleman, and Elissa J Chesler

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A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice., Jason A. Bubier, Vivek M. Philip, Christopher Quince, James Campbell, Yanjiao Zhou, Tatiana Vishnivetskaya, Suman Duvvuru, Rachel Hageman Blair, Juliet Ndukum, Kevin D Donohue, Carmen M Foster, David J Mellert, George M. Weinstock, Cymbeline T Culiat, Bruce F O'Hara, Anthony V Palumbo, Mircea Podar, and Elissa J Chesler

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Human and mouse essentiality screens as a resource for disease gene discovery., Pilar Cacheiro, Violeta Muñoz-Fuentes, Stephen A. Murray, Mary E Dickinson, Maja Bucan, Lauryl M J Nutter, Kevin A Peterson, Hamed Haselimashhadi, Ann M Flenniken, Hugh Morgan, Henrik Westerberg, Tomasz Konopka, Chih-Wei Hsu, Audrey Christiansen, Denise G Lanza, Arthur L Beaudet, Jason D Heaney, Helmut Fuchs, Valerie Gailus-Durner, Tania Sorg, Jan Prochazka, Vendula Novosadova, Christopher J Lelliott, Hannah Wardle-Jones, Sara Wells, Lydia Teboul, Heather Cater, Michelle Stewart, Tertius Hough, Wolfgang Wurst, Radislav Sedlacek, David J Adams, John R Seavitt, Glauco Tocchini-Valentini, Fabio Mammano, Robert E Braun, Colin McKerlie, Yann Herault, Martin Hrabě de Angelis, Ann-Marie Mallon, K C Kent Lloyd, Steve D M Brown, Helen Parkinson, Terrence F Meehan, Damian Smedley, Genomics England Research Consortium, and International Mouse Phenotyping Consortium

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Structural Variant in Mitochondrial-Associated Gene (MRPL3) Induces Adult-Onset Neurodegeneration with Memory Impairment in the Mouse., Lindsay S Cahill, Jessie M Cameron, Julie Winterburn, Patrick Macos, Johnathan Hoggarth, Misko Dzamba, Michael Brudno, Lauryl M J Nutter, Thomas J. Sproule, Robert W. Burgess, R Mark Henkelman, and John G Sled

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Long noncoding RNA SMUL suppresses SMURF2 production-mediated muscle atrophy via nonsense-mediated mRNA decay., Bolin Cai, Zhenhui Li, Manting Ma, Jing Zhang, Shaofen Kong, Bahareldin Ali Abdalla, Haiping Xu, Endashaw Jebessa, Xiquan Zhang, Raman Akinyanju Lawal, and Qinghua Nie

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Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells., Zhigang Cai, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J Kotzin, Martin Carroll, Gerald Wertheim, Adam Williams, Sarath Chandra Janga, Chi Zhang, Jorge Henao-Mejia, and Reuben Kapur

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Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia., Zhigang Cai, Chi Zhang, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, and Reuben Kapur

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Methods for comparative ChIA-PET and Hi-C data analysis., Dan Capurso, Zhonghui Tang, and Yijun Ruan

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Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes., Leigh Carmody, Hannah Blau, Daniel Danis, Xingman A Zhang, Jean-Philippe Gourdine, Nicole Vasilevsky, Peter Krawitz, Miles D Thompson, and Peter N Robinson

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Genetic Identification and Drug-Resistance Characterization of, Jorge Cervantes, Noemí Yokobori, and Bo-Young Hong

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AbGRI4, a novel antibiotic resistance island in multiply antibiotic-resistant Acinetobacter baumannii clinical isolates., Agnes P Chan, Yongwook Choi, Thomas H Clarke, Lauren M Brinkac, Richard C White, Michael R Jacobs, Robert A Bonomo, Mark D Adams, and Derrick E Fouts

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Phenotate: crowdsourcing phenotype annotations as exercises in undergraduate classes., Willie H Chang, Pouria Mashouri, Alexander X Lozano, Brittney Johnstone, Mia Husić, Annie Olry, Sylvie Maiella, Tugce B Balci, Sarah L Sawyer, Peter N Robinson, Ana Rath, and Michael Brudno

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Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype-like Cluster., Yanfei Chen, Masako Nakanishi, Eddy J Bautista, Veneta Qendro, Erica Sodergren, Daniel W Rosenberg, and George M. Weinstock

Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling., Sumana R Chintapaludi, Asli Uyar, Harriet M. Jackson, Casey Acklin, Xulong Wang, Michael Sasner, Gregory W. Carter, and Gareth R Howell

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Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics., Kwangbom Choi, Yang Chen, Daniel A Skelly, and Gary A Churchill

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Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers., Sung-Yup Cho, Yumi Oh, Eui Man Jeong, Sanghui Park, Dakeun Lee, Xiaorui Wang, Qiqi Zeng, Hongyu Qin, Fang Hu, Hui Gong, Xi Liu, Guanjun Zhang, Deukchae Na, Jieun Lee, Jeesoo Chae, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, Jong-Il Kim, Hansoo Park, Chengsheng Zhang, Han-Kwang Yang, and Charles Lee

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An Improved Phenotype-Driven Tool for Rare Mendelian Variant Prioritization: Benchmarking Exomiser on Real Patient Whole-Exome Data., Valentina Cipriani, Nikolas Pontikos, Gavin Arno, Panagiotis I Sergouniotis, Eva Lenassi, Penpitcha Thawong, Daniel Danis, Michel Michaelides, Andrew R Webster, Anthony T Moore, Peter N Robinson, Julius O B Jacobsen, and Damian Smedley

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Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss., Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F Hyde, Lisa Stone, Patsy M. Nishina, Mark P. Krebs, and Juergen K. Naggert

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Disruption in murine Eml1 perturbs retinal lamination during early development., Gayle B. Collin, J Won, Mark P. Krebs, W J Hicks, Jeremy R. Charette, Juergen K. Naggert, and Patsy M. Nishina

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Tryptophan catabolism reflects disease activity in human tuberculosis., Jeffrey M Collins, Amnah Siddiqa, Dean P Jones, Ken Liu, Russell R Kempker, Azhar Nizam, N Sarita Shah, Nazir Ismail, Samuel G Ouma, Nestani Tukvadze, Shuzhao Li, Cheryl L Day, Jyothi Rengarajan, James Cm Brust, Neel R Gandhi, Joel D Ernst, Henry M Blumberg, and Thomas R Ziegler

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What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?, Bella Luna Colombini-Ishikiriama, Thiago Jose Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha de Oliveira, Vanessa Soares Lara, Andrew S Greene, and Carlos Ferreira Santos

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Dapagliflozin Does Not Directly Affect Human α or β Cells., Chunhua Dai, John T Walker, Alena Shostak, Yasir Bouchi, Greg Poffenberger, Nathaniel J Hart, David A Jacobson, M Wade Calcutt, Rita Bottino, Dale L Greiner, Leonard D. Shultz, Owen P McGuinness, E Danielle Dean, and Alvin C Powers

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Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable., Chunhua Dai, John T Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle Dean, Nripesh Prasad, Shawn E Levy, Dale L Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C Powers

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3D bioprinting for reconstituting the cancer microenvironment., Pallab Datta, Madhuri Dey, Zaman Ataie, Derya Unutmaz, and Ibrahim T Ozbolat

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Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis., Udita Datta, Sarah E Schoenrock, Jason A. Bubier, Molly A. Bogue, James D Jentsch, Ryan W Logan, Lisa M Tarantino, and Elissa J Chesler

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Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice., Ivy L Debreceni, Michael S Chimenti, David V. Serreze, Aron M Geurts, Yi-Guang Chen, and Scott M Lieberman

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Stimulus Complexity and Mouse Strain Drive Escalation of Operant Sensation Seeking Within and Across Sessions in C57BL/6J and DBA/2J Mice., Price E. Dickson and Guy Mittleman

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Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using d-Alanine Auxotrophy., David Dodds, Jeffrey L Bose, Ming-De Deng, Gilles R Dubé, Trudy H Grossman, Alaina Kaiser, Kashmira Kulkarni, Roger Leger, Sara Mootien-Boyd, Azim Munivar, Julia Oh, Matthew Pestrak, Komal Rajpura, Alexander P Tikhonov, Traci Turecek, and Travis Whitfill

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Investigation of COVID-19 comorbidities reveals genes and pathways coincident with the SARS-CoV-2 viral disease., Mary E. Dolan, David P. Hill, Gaurab Mukherjee, Monica McAndrews, Elissa J Chesler, and Judith A. Blake

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Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study., Kaspar Draaisma, Aikaterini Chatzipli, Martin Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Slávka Lukacova, Giuseppe Lombardi, Sieger Leenstra, Monique Hanse, Ruth Fleischeuer, Colin Watts, Joseph McAbee, Nicos Angelopoulos, Thierry Gorlia, Vassilis Golfinopoulos, Johan M Kros, Roel G W Verhaak, Vincent Bours, Martin J van den Bent, Ultan McDermott, Pierre A Robe, and Pim J French

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Bioinformatics Core Survey Highlights the Challenges Facing Data Analysis Facilities., Julie A Dragon, Chris Gates, Shannan Ho Sui, John N Hutchinson, Radha Krishna Murthy Karuturi, Alper Kucukural, Shawn Polson, Alberto Riva, Matthew Lee Settles, Jyothi Thimmapuram, and Stuart S Levine

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CRISPR artificial splicing factors., Menghan Du, Nathaniel L. Jillette, Jacqueline Jufen Zhu, Sheng Li, and Albert Wu Cheng

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Genetic variants and functional pathways associated with resilience to Alzheimer's disease., Logan Dumitrescu, Emily R Mahoney, Shubhabrata Mukherjee, Michael L Lee, William S Bush, Corinne D Engelman, Qiongshi Lu, David W Fardo, Emily H Trittschuh, Jesse Mez, Catherine Kaczorowski, Hector Hernandez Saucedo, Keith F Widaman, Rachel Buckley, Michael Properzi, Elizabeth Mormino, Hyun-Sik Yang, Tessa Harrison, Trey Hedden, Kwangsik Nho, Shea J Andrews, Doug Tommet, Niran Hadad, R Elizabeth Sanders, Douglas M Ruderfer, Katherine A Gifford, Annah M Moore, Francis Cambronero, Xiaoyuan Zhong, Neha S Raghavan, Badri Vardarajan, Margaret A Pericak-Vance, Lindsay A Farrer, Li-San Wang, Carlos Cruchaga, Gerard Schellenberg, Nancy J Cox, Jonathan L Haines, C Dirk Keene, Andrew J Saykin, Eric B Larson, Reisa A Sperling, Richard Mayeux, David A Bennett, Julie A Schneider, Paul K Crane, Angela L Jefferson, and Timothy J Hohman

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Evolution: Is Recombination Rate Variation Adaptive?, Beth L Dumont

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Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel., Amy R Dunn, Niran Hadad, Sarah M Neuner, Ji-Gang Zhang, Vivek M. Philip, Logan Dumitrescu, Timothy J Hohman, Jeremy H Herskowitz, Kristen M S O'Connell, and Catherine Kaczorowski

TRPV4 Antagonism Prevents Mechanically Induced Myotonia., Chris Dupont, Kevin Novak, Kirsten Denman, Jessica H Myers, Jeremy M Sullivan, Phillip V Walker, Nicklaus L Brown, David R Ladle, Laurent P. Bogdanik, Cathleen Lutz, Andrew A Voss, Charlotte J Sumner, and Mark M Rich

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Cancer Stem Cells: Notes for Authors., Connie J Eaves and Martin Pera

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Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and γ-ray-induced tumors., E F Edmondson, Daniel M Gatti, F A Ray, E L Garcia, C M Fallgren, D A Kamstock, and M M Weil

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Comprehensive overview of COVID-19 clinical trials., Kiran Ejaz, Tanveer Kauser, and Amnah Siddiqa

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Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks., Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Sai K Balchand, Jeffrey D Servetas, Aimée Zuniga, Rolf Zeller, Brian Gebelein, Matthew T Weirauch, Kevin A Peterson, and Samantha A Brugmann

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Metagenomic growth rate inferences of strains in situ., Akintunde Emiola, Wei Zhou, and Julia Oh

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Teasing the Immune System to Repair the Heart., Jonathan A Epstein, Nadia Rosenthal, and Arthur M Feldman

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Precise Spatiotemporal Control of Nodal Na, Yael Eshed-Eisenbach, Jerome Devaux, Anna Vainshtein, Ofra Golani, Se-Jin Lee, Konstantin Feinberg, Natasha Sukhanov, Daniel S Greenspan, Keiichiro Susuki, Matthew N Rasband, and Elior Peles

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Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis., Yvonne A Evrard, Anuj Srivastava, Jelena Randjelovic, James H Doroshow, Dennis A Dean, Jeffrey S Morris, Jeffrey H Chuang, and NCI PDXNet Consortium

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Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats., Eric C Exner, Aron M Geurts, Brian R Hoffmann, Marc Casati, Timothy Stodola, Nikita R Dsouza, Michael Zimmermann, Julian H Lombard, and Andrew S Greene

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Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands., M Heath Farris, Pamela A Texter, Agustin A Mora, Michael V. Wiles, Ellen F Mac Garrigle, Sybil A Klaus, and Kristine Rosfjord

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CsrA Supports both Environmental Persistence and Host-Associated Growth of Acinetobacter baumannii., John M Farrow, Greg Wells, Samantha Palethorpe, Mark D Adams, and Everett C Pesci

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The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137, Bardees M Foda, Ashley E Ciecko, David V. Serreze, William M Ridgway, Aron M Geurts, and Yi-Guang Chen

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Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling., Elvira Forte, Sandra Daigle, and Nadia Rosenthal

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Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice., Elvira Forte, Daniel A Skelly, Mandy Chen, Sandra Daigle, Kaesi A Morelli, Olivia Hon, Vivek M. Philip, Mauro W Costa, Nadia Rosenthal, and Milena B Furtado

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Lipidomic Profiling of the Epidermis in a Mouse Model of Dermatitis Reveals Sexual Dimorphism and Changes in Lipid Composition before the Onset of Clinical Disease., Jackeline Franco, Bartek Rajwa, Christina R Ferreira, John P Sundberg, and Harm HogenEsch

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Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation., Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F. Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M. Lutz, Markus Affolter, Aamir Zuberi, and Hamed Jafar-Nejad

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An expanded mouse testis transcriptome and mass spectrometry defines novel proteins., Jaya Gamble, Joel Chick, Kelly Seltzer, Joel H Graber, Steven Gygi, Robert E Braun, and Elizabeth M Snyder

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Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy., Peiheng Gan, Michaela Patterson, Hirofumi Watanabe, Kristy Wang, Reilly A Edmonds, Laura G Reinholdt, and Henry M Sucov

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Using Genetic and Species Diversity to Tackle Kidney Disease., Michael R Garrett and Ron Korstanje

Supplementation of the ESID registry working definitions for the clinical diagnosis of inborn errors of immunity with encoded human phenotype ontology (HPO) terms., Lukas M Gasteiger, Peter N Robinson, Julia Pazmandi, Kaan Boztug, Mikko R J Seppänen, and Markus G Seidel

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The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice., Valeria Gerbino, Esther Kaunga, Junqiang Ye, Daniele Canzio, Sean O'Keeffe, Noam D Rudnick, Paolo Guarnieri, Cathleen Lutz, and Tom Maniatis

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Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity., Leah C. Graham, Heidi Kocalis, Ileana Soto, and Gareth R Howell

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Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites., Elie Hammam, Guruprasad Ananda, Ameya Sinha, Christine Scheidig-Benatar, Mylene Bohec, Peter R Preiser, Peter C Dedon, Artur Scherf, and Shruthi S Vembar

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The XY body: an attractive chromatin domain., Mary Ann Handel

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circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan., Shahnaz Haque, Ryan M Ames, Karen Moore, Luke C Pilling, Luanne L. Peters, Stefania Bandinelli, Luigi Ferrucci, and Lorna W Harries

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Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin., Jeffrey M. Harder, Chelsea Guymer, John P M Wood, Evangelia Daskalaki, Glyn Chidlow, Chi Zhang, Revathi Balasubramanian, Brynn H Cardozo, Nicole E Foxworth, Kelly E Deering, Tionna B Ouellette, Christa Montgomery, Craig E Wheelock, Robert J Casson, Pete A Williams, and Simon W M John

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Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice., Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongyuan Yang, Jocelyn M Thomas, Nicole E Foxworth, Simon W M John, and Gareth R Howell

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Soft windowing application to improve analysis of high-throughput phenotyping data., Hamed Haselimashhadi, Jeremy C Mason, Violeta Munoz-Fuentes, Federico López-Gómez, Kolawole Babalola, Elif F Acar, Vivek Kumar, Jacqui White, Ann M Flenniken, Ruairidh King, Ewan Straiton, John Richard Seavitt, Angelina Gaspero, Arturo Garza, Audrey E Christianson, Chih-Wei Hsu, Corey L Reynolds, Denise G Lanza, Isabel Lorenzo, Jennie R Green, Juan J Gallegos, Ritu Bohat, Rodney C Samaco, Surabi Veeraragavan, Jong Kyoung Kim, Gregor Miller, Helmult Fuchs, Lillian Garrett, Lore Becker, Yeon Kyung Kang, David Clary, Soo Young Cho, Masaru Tamura, Nobuhiko Tanaka, Kyung Dong Soo, Alexandr Bezginov, Ghina Bou About, Marie-France Champy, Laurent Vasseur, Sophie Leblanc, Hamid Meziane, Mohammed Selloum, Patrick T Reilly, Nadine Spielmann, Holger Maier, Valerie Gailus-Durner, Tania Sorg, Masuya Hiroshi, Obata Yuichi, Jason D Heaney, Mary E Dickinson, Wurst Wolfgang, Glauco P Tocchini-Valentini, Kevin C Kent Lloyd, Colin McKerlie, Je Kyung Seong, Herault Yann, Martin Hrabé de Angelis, Steve D M Brown, Damian Smedley, Paul Flicek, Ann-Marie Mallon, Helen Parkinson, and Terrence F Meehan

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The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities., Eleanor Herbert, Michelle Stewart, Marie Hutchison, Ann M Flenniken, Dawei Qu, Lauryl M J Nutter, Colin McKerlie, Liane Hobson, Brenda Kick, Bonnie L. Lyons, Jean-Paul Wiegand, Rosalinda A. Doty, Juan Antonio Aguilar-Pimentel, Martin Hrabe de Angelis, Mary Dickinson, John Seavitt, Jacqueline K White, Cheryl L Scudamore, and Sara Wells

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Low SATB1 Expression Promotes IL-5 and IL-9 Expression in Sézary Syndrome., Alberto Herrera, Simon Fredholm, Anthony Cheng, Eleni P Mimitou, Angelina Seffens, Michal Bar-Natan, Amy Sun, Jo-Ann Latkowski, Andreas Willerslew-Olsen, Terkild B Buus, Maria Gluud, Thorbjørn Krejsgaard, Sara Torres-Rusillo, Charlotte Menné Bonefeld, Anders Woetmann, Carsten Geisler, Larisa J Geskin, Zhengqing Ouyang, Peter Smibert, Niels Ødum, and Sergei B Koralov

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Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice., Sarah E Heuer, Sarah M Neuner, Niran Hadad, Kristen M S O'Connell, Robert W Williams, Vivek M. Philip, Chris Gaiteri, and Catherine Kaczorowski

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ACTIVating Resources for the COVID-19 Pandemic: In Vivo Models for Vaccines and Therapeutics., Judith A Hewitt, Cathleen Lutz, William C Florence, M Louise M Pitt, Srinivas Rao, Jay Rappaport, and Nancy L Haigwood

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Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells., Yoshiki Higashijima, Yusuke Matsui, Teppei Shimamura, Ryo Nakaki, Nao Nagai, Shuichi Tsutsumi, Yohei Abe, Verena M Link, Mizuko Osaka, Masayuki Yoshida, Ryo Watanabe, Toshihiro Tanaka, Akashi Taguchi, Mai Miura, Xiaoan Ruan, Guoliang Li, Tsuyoshi Inoue, Masaomi Nangaku, Hiroshi Kimura, Tetsushi Furukawa, Hiroyuki Aburatani, Youichiro Wada, Yijun Ruan, Christopher K Glass, and Yasuharu Kanki

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Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice., David A Hillis, Liran Yadgary, George M. Weinstock, Fernando Pardo-Manuel de Villena, Daniel Pomp, Alexandra S Fowler, Shizhong Xu, Frank Chan, and Theodore Garland

Modifiable Lifestyle Factors in Alzheimer Disease: An Opportunity to Transform the Therapeutic Landscape Through Transdisciplinary Collaboration., Timothy J Hohman and Catherine Kaczorowski

The Salivary Mycobiome Contains 2 Ecologically Distinct Mycotypes., Bo-Young Hong, A Hoare, A Cardenas, A K Dupuy, L Choquette, A L Salner, P K Schauer, U Hegde, D E Peterson, A Dongari-Bagtzoglou, L D Strausbaugh, and P I Diaz

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Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation., Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace Stafford, Vivek Kohar, Leonard D. Shultz, and Michael V. Wiles