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Submissions from 2020

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The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma., Sophia Adamia, Ivane Abiatari, Samir Amin, Mariateresa Fulciniti, Stephane Minvielle, Cheng Li, Philippe Moreau, Herve Avet-Loiseau, Nikhil C Munshi, and Kenneth C Anderson

Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in, Mark D Adams, Fernando Pasteran, German M Traglia, Jasmine Martinez, Fanny Huang, Christine Liu, Jennifer S Fernandez, Carolina Lopez, Lisandro J Gonzalez, Ezequiel Albornoz, Alejandra Corso, Alejandro J Vila, Robert A Bonomo, and Maria Soledad Ramirez

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Artificial intelligence with multi-functional machine learning platform development for better healthcare and precision medicine., Zeeshan Ahmed, Khalid Mohamed, Saman Zeeshan, and XinQi Dong

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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer., Kadir C Akdemir, Victoria T Le, Sahaana Chandran, Yilong Li, Roel G W Verhaak, Rameen Beroukhim, Peter J Campbell, Lynda Chin, Jesse R Dixon, P Andrew Futreal, PCAWG Structural Variation Working Groug, and PCAWG Consortium

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Comparative Molecular Life History of Spontaneous Canine and Human Gliomas., Samirkumar B Amin, Kevin J Anderson, C Elizabeth Boudreau, Emmanuel Martinez-Ledesma, Emre Kocakavuk, Kevin C Johnson, Floris P Barthel, Frederick S Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barter, Ching C Lau, Chew Yee Ngan, Margaret Chapman, Jennifer W Koehler, James P Long, Andrew D Miller, C Ryan Miller, Brian F Porter, Daniel R Rissi, Christina Mazcko, Amy K LeBlanc, Peter J Dickinson, Rebecca A Packer, Amanda R Taylor, John H Rossmeisl, Kevin D Woolard, Amy B Heimberger, Jonathan M Levine, and Roel G W Verhaak

The influence of uncertainty and uncertainty tolerance on attitudes and self-efficacy about genomic tumor testing., Eric C Anderson, Alexandra Hinton, Christine W Lary, Tania Strout, Andrey Antov, Emily A Edelman, Petra Helbig, Kate Reed, Jens Rueter, and Paul K J Han

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Molecular and clonal evolution in recurrent metastatic gliosarcoma., Kevin J Anderson, Aaron C Tan, Jonathon Parkinson, Michael Back, Marina Kastelan, Allison Newey, Janice Brewer, Helen Wheeler, Amanda L Hudson, Samirkumar B Amin, Kevin C Johnson, Floris P Barthel, Roel G W Verhaak, and Mustafa Khasraw

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Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data., Haitham Ashoor, Xiaowen Chen, Wojciech Rosikiewicz, Jiahui Wang, Albert Cheng, Ping Wang, Yijun Ruan, and Sheng Li

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A guide to writing systematic reviews of rare disease treatments to generate FAIR-compliant datasets: building a Treatabolome., Antonio Atalaia, Rachel Thompson, Alberto Corvo, Leigh Carmody, Davide Piscia, Leslie Matalonga, Alfons Macaya, Angela Lochmuller, Bertrand Fontaine, Birte Zurek, Carles Hernandez-Ferrer, Carola Rheinard, David Gómez-Andrés, Jean-François Desaphy, Katherine Schon, Katja Lohmann, Matthew J Jennings, Matthis Synofzik, Olaf Riess, Rabah Ben Yaou, Teresinha Evangelista, Thiloka Ratnaike, Virginie Bros-Facer, Gulcin Gumus, Rita Horvath, Patrick Chinnery, Steven Laurie, Holm Graessner, Peter N Robinson, Hanns Lochmuller, Sergi Beltran, and Gisèle Bonne

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Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B., Ana Rita Batista, Oliver D King, Christopher P Reardon, Crystal Davis, Shankaracharya, Vivek M. Philip, Heather Gray-Edwards, Neil Aronin, Cathleen Lutz, John Landers, and Miguel Sena-Esteves

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Know Your Model: How essential is that essential gene?, Susan M. Bello, Melissa L. Berry, and Cynthia L Smith

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Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma., Noah E Berlow, Catherine S Grasso, Michael J Quist, Mingshan Cheng, Regina Gandour-Edwards, Brian S Hernandez, Joel E Michalek, Christopher Ryan, Paul Spellman, Ranadip Pal, Lynn S Million, Mark Renneker, and Charles Keller

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Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data., Molly A. Bogue, Vivek M. Philip, David O Walton, Stephen C. Grubb, Matthew H Dunn, Georgi Kolishovski, Jake Emerson, Gaurab Mukherjee, Timothy M Stearns, Hao He, Vinita Sinha, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, and Elissa J Chesler

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Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells., Marion Bouvet, Olivier Claude, Maguelonne Roux, Daniel A Skelly, Nihar Masurkar, Nathalie Mougenot, Sophie Nadaud, Catherine Blanc, Clément Delacroix, Solenne Chardonnet, Cédric Pionneau, Claire Perret, Elisa Yaniz-Galende, Nadia Rosenthal, David-Alexandre Trégouët, Giovanna Marazzi, Jean-Sébastien Silvestre, David Sassoon, and Jean-Sébastien Hulot

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Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice., Jane Branca, Benjamin E. Low, Ruth L. Saxl, Jennifer K Sargent, Rosalinda A. Doty, Michael V. Wiles, Beth L Dumont, and Muneer G. Hasham

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Sensitivity of comorbidity network analysis., Jason Cory Brunson, Thomas P Agresta, and Reinhard Laubenbacher

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Genetic variation regulates opioid-induced respiratory depression in mice., Jason A. Bubier, Hao He, Vivek M. Philip, Tyler A. Roy, Christian Monroy Hernandez, Rebecca Bernat, Kevin D Donohue, Bruce F O'Hara, and Elissa J Chesler

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Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis, Jason A. Bubier, Vivek M. Philip, Price E. Dickson, Guy Mittleman, and Elissa J Chesler

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A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice., Jason A. Bubier, Vivek M. Philip, Christopher Quince, James Campbell, Yanjiao Zhou, Tatiana Vishnivetskaya, Suman Duvvuru, Rachel Hageman Blair, Juliet Ndukum, Kevin D Donohue, Carmen M Foster, David J Mellert, George M. Weinstock, Cymbeline T Culiat, Bruce F O'Hara, Anthony V Palumbo, Mircea Podar, and Elissa J Chesler

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Human and mouse essentiality screens as a resource for disease gene discovery., Pilar Cacheiro, Violeta Muñoz-Fuentes, Stephen A. Murray, Mary E Dickinson, Maja Bucan, Lauryl M J Nutter, Kevin A Peterson, Hamed Haselimashhadi, Ann M Flenniken, Hugh Morgan, Henrik Westerberg, Tomasz Konopka, Chih-Wei Hsu, Audrey Christiansen, Denise G Lanza, Arthur L Beaudet, Jason D Heaney, Helmut Fuchs, Valerie Gailus-Durner, Tania Sorg, Jan Prochazka, Vendula Novosadova, Christopher J Lelliott, Hannah Wardle-Jones, Sara Wells, Lydia Teboul, Heather Cater, Michelle Stewart, Tertius Hough, Wolfgang Wurst, Radislav Sedlacek, David J Adams, John R Seavitt, Glauco Tocchini-Valentini, Fabio Mammano, Robert E Braun, Colin McKerlie, Yann Herault, Martin Hrabě de Angelis, Ann-Marie Mallon, K C Kent Lloyd, Steve D M Brown, Helen Parkinson, Terrence F Meehan, Damian Smedley, Genomics England Research Consortium, and International Mouse Phenotyping Consortium

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Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells., Zhigang Cai, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J Kotzin, Martin Carroll, Gerald Wertheim, Adam Williams, Sarath Chandra Janga, Chi Zhang, Jorge Henao-Mejia, and Reuben Kapur

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Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia., Zhigang Cai, Chi Zhang, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, and Reuben Kapur

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Methods for comparative ChIA-PET and Hi-C data analysis., Dan Capurso, Zhonghui Tang, and Yijun Ruan

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Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes., Leigh Carmody, Hannah Blau, Daniel Danis, Xingman A Zhang, Jean-Philippe Gourdine, Nicole Vasilevsky, Peter Krawitz, Miles D Thompson, and Peter N Robinson

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AbGRI4, a novel antibiotic resistance island in multiply antibiotic-resistant Acinetobacter baumannii clinical isolates., Agnes P Chan, Yongwook Choi, Thomas H Clarke, Lauren M Brinkac, Richard C White, Michael R Jacobs, Robert A Bonomo, Mark D Adams, and Derrick E Fouts

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Phenotate: crowdsourcing phenotype annotations as exercises in undergraduate classes., Willie H Chang, Pouria Mashouri, Alexander X Lozano, Brittney Johnstone, Mia Husić, Annie Olry, Sylvie Maiella, Tugce B Balci, Sarah L Sawyer, Peter N Robinson, Ana Rath, and Michael Brudno

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Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype-like Cluster., Yanfei Chen, Masako Nakanishi, Eddy J Bautista, Veneta Qendro, Erica Sodergren, Daniel W Rosenberg, and George M. Weinstock

Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling., Sumana R Chintapaludi, Asli Uyar, Harriet M. Jackson, Casey Acklin, Xulong Wang, Michael Sasner, Gregory W. Carter, and Gareth R Howell

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Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics., Kwangbom Choi, Yang Chen, Daniel A Skelly, and Gary A Churchill

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Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers., Sung-Yup Cho, Yumi Oh, Eui Man Jeong, Sanghui Park, Dakeun Lee, Xiaorui Wang, Qiqi Zeng, Hongyu Qin, Fang Hu, Hui Gong, Xi Liu, Guanjun Zhang, Deukchae Na, Jieun Lee, Jeesoo Chae, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, Jong-Il Kim, Hansoo Park, Chengsheng Zhang, Han-Kwang Yang, and Charles Lee

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An Improved Phenotype-Driven Tool for Rare Mendelian Variant Prioritization: Benchmarking Exomiser on Real Patient Whole-Exome Data., Valentina Cipriani, Nikolas Pontikos, Gavin Arno, Panagiotis I Sergouniotis, Eva Lenassi, Penpitcha Thawong, Daniel Danis, Michel Michaelides, Andrew R Webster, Anthony T Moore, Peter N Robinson, Julius O B Jacobsen, and Damian Smedley

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Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss., Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F Hyde, Lisa Stone, Patsy M. Nishina, Mark P. Krebs, and Juergen K. Naggert

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Disruption in murine Eml1 perturbs retinal lamination during early development., Gayle B. Collin, J Won, Mark P. Krebs, W J Hicks, Jeremy R. Charette, Juergen K. Naggert, and Patsy M. Nishina

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What is the response profile of deciduous pulp fibroblasts stimulated with E. coli LPS and E. faecalis LTA?, Bella Luna Colombini-Ishikiriama, Thiago Jose Dionisio, Thais Francini Garbieri, Rafaela Alves da Silva, Maria Aparecida Andrade Moreira Machado, Sandra Helena Penha de Oliveira, Vanessa Soares Lara, Andrew S Greene, and Carlos Ferreira Santos

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Dapagliflozin Does Not Directly Affect Human α or β Cells., Chunhua Dai, John T Walker, Alena Shostak, Yasir Bouchi, Greg Poffenberger, Nathaniel J Hart, David A Jacobson, M Wade Calcutt, Rita Bottino, Dale L Greiner, Leonard D. Shultz, Owen P McGuinness, E Danielle Dean, and Alvin C Powers

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Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable., Chunhua Dai, John T Walker, Alena Shostak, Ana Padgett, Erick Spears, Scott Wisniewski, Greg Poffenberger, Radhika Aramandla, E Danielle Dean, Nripesh Prasad, Shawn E Levy, Dale L Greiner, Leonard D. Shultz, Rita Bottino, and Alvin C Powers

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3D bioprinting for reconstituting the cancer microenvironment., Pallab Datta, Madhuri Dey, Zaman Ataie, Derya Unutmaz, and Ibrahim T Ozbolat

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Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis., Udita Datta, Sarah E Schoenrock, Jason A. Bubier, Molly A. Bogue, James D Jentsch, Ryan W Logan, Lisa M Tarantino, and Elissa J Chesler

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Stimulus Complexity and Mouse Strain Drive Escalation of Operant Sensation Seeking Within and Across Sessions in C57BL/6J and DBA/2J Mice., Price E. Dickson and Guy Mittleman

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Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using d-Alanine Auxotrophy., David Dodds, Jeffrey L Bose, Ming-De Deng, Gilles R Dubé, Trudy H Grossman, Alaina Kaiser, Kashmira Kulkarni, Roger Leger, Sara Mootien-Boyd, Azim Munivar, Julia Oh, Matthew Pestrak, Komal Rajpura, Alexander P Tikhonov, Traci Turecek, and Travis Whitfill

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Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study., Kaspar Draaisma, Aikaterini Chatzipli, Martin Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Slávka Lukacova, Giuseppe Lombardi, Sieger Leenstra, Monique Hanse, Ruth Fleischeuer, Colin Watts, Joseph McAbee, Nicos Angelopoulos, Thierry Gorlia, Vassilis Golfinopoulos, Johan M Kros, Roel G W Verhaak, Vincent Bours, Martin J van den Bent, Ultan McDermott, Pierre A Robe, and Pim J French

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CRISPR artificial splicing factors., Menghan Du, Nathaniel L. Jillette, Jacqueline Jufen Zhu, Sheng Li, and Albert Wu Cheng

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Evolution: Is Recombination Rate Variation Adaptive?, Beth L Dumont

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Cancer Stem Cells: Notes for Authors., Connie J Eaves and Martin Pera

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Genomic mapping in outbred mice reveals overlap in genetic susceptibility for HZE ion- and γ-ray-induced tumors., E F Edmondson, Daniel M Gatti, F A Ray, E L Garcia, C M Fallgren, D A Kamstock, and M M Weil

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Comprehensive overview of COVID-19 clinical trials., Kiran Ejaz, Tanveer Kauser, and Amnah Siddiqa

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Metagenomic growth rate inferences of strains in situ., Akintunde Emiola, Wei Zhou, and Julia Oh

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Teasing the Immune System to Repair the Heart., Jonathan A Epstein, Nadia Rosenthal, and Arthur M Feldman

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Precise Spatiotemporal Control of Nodal Na, Yael Eshed-Eisenbach, Jerome Devaux, Anna Vainshtein, Ofra Golani, Se-Jin Lee, Konstantin Feinberg, Natasha Sukhanov, Daniel S Greenspan, Keiichiro Susuki, Matthew N Rasband, and Elior Peles

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Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis., Yvonne A Evrard, Anuj Srivastava, Jelena Randjelovic, James H Doroshow, Dennis A Dean, Jeffrey S Morris, Jeffrey H Chuang, and NCI PDXNet Consortium

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Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats., Eric C Exner, Aron M Geurts, Brian R Hoffmann, Marc Casati, Timothy Stodola, Nikita R Dsouza, Michael Zimmermann, Julian H Lombard, and Andrew S Greene

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The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137, Bardees M Foda, Ashley E Ciecko, David V. Serreze, William M Ridgway, Aron M Geurts, and Yi-Guang Chen

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Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice., Elvira Forte, Daniel A Skelly, Mandy Chen, Sandra Daigle, Kaesi A Morelli, Olivia Hon, Vivek M. Philip, Mauro W Costa, Nadia Rosenthal, and Milena B Furtado

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Lipidomic Profiling of the Epidermis in a Mouse Model of Dermatitis Reveals Sexual Dimorphism and Changes in Lipid Composition before the Onset of Clinical Disease., Jackeline Franco, Bartek Rajwa, Christina R Ferreira, John P Sundberg, and Harm HogenEsch

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Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation., Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F. Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M. Lutz, Markus Affolter, Aamir Zuberi, and Hamed Jafar-Nejad

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An expanded mouse testis transcriptome and mass spectrometry defines novel proteins., Jaya Gamble, Joel Chick, Kelly Seltzer, Joel H Graber, Steven Gygi, Robert E Braun, and Elizabeth M Snyder

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Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy., Peiheng Gan, Michaela Patterson, Hirofumi Watanabe, Kristy Wang, Reilly A Edmonds, Laura G Reinholdt, and Henry M Sucov

Supplementation of the ESID registry working definitions for the clinical diagnosis of inborn errors of immunity with encoded human phenotype ontology (HPO) terms., Lukas M Gasteiger, Peter N Robinson, Julia Pazmandi, Kaan Boztug, Mikko R J Seppänen, and Markus G Seidel

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The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice., Valeria Gerbino, Esther Kaunga, Junqiang Ye, Daniele Canzio, Sean O'Keeffe, Noam D Rudnick, Paolo Guarnieri, Cathleen Lutz, and Tom Maniatis

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Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity., Leah C. Graham, Heidi Kocalis, Ileana Soto, and Gareth R Howell

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Discovery of a new predominant cytosine DNA modification that is linked to gene expression in malaria parasites., Elie Hammam, Guruprasad Ananda, Ameya Sinha, Christine Scheidig-Benatar, Mylene Bohec, Peter R Preiser, Peter C Dedon, Artur Scherf, and Shruthi S Vembar

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The XY body: an attractive chromatin domain., Mary Ann Handel

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circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan., Shahnaz Haque, Ryan M Ames, Karen Moore, Luke C Pilling, Luanne L. Peters, Stefania Bandinelli, Luigi Ferrucci, and Lorna W Harries

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Soft windowing application to improve analysis of high-throughput phenotyping data., Hamed Haselimashhadi, Jeremy C Mason, Violeta Munoz-Fuentes, Federico López-Gómez, Kolawole Babalola, Elif F Acar, Vivek Kumar, Jacqui White, Ann M Flenniken, Ruairidh King, Ewan Straiton, John Richard Seavitt, Angelina Gaspero, Arturo Garza, Audrey E Christianson, Chih-Wei Hsu, Corey L Reynolds, Denise G Lanza, Isabel Lorenzo, Jennie R Green, Juan J Gallegos, Ritu Bohat, Rodney C Samaco, Surabi Veeraragavan, Jong Kyoung Kim, Gregor Miller, Helmult Fuchs, Lillian Garrett, Lore Becker, Yeon Kyung Kang, David Clary, Soo Young Cho, Masaru Tamura, Nobuhiko Tanaka, Kyung Dong Soo, Alexandr Bezginov, Ghina Bou About, Marie-France Champy, Laurent Vasseur, Sophie Leblanc, Hamid Meziane, Mohammed Selloum, Patrick T Reilly, Nadine Spielmann, Holger Maier, Valerie Gailus-Durner, Tania Sorg, Masuya Hiroshi, Obata Yuichi, Jason D Heaney, Mary E Dickinson, Wurst Wolfgang, Glauco P Tocchini-Valentini, Kevin C Kent Lloyd, Colin McKerlie, Je Kyung Seong, Herault Yann, Martin Hrabé de Angelis, Steve D M Brown, Damian Smedley, Paul Flicek, Ann-Marie Mallon, Helen Parkinson, and Terrence F Meehan

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The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities., Eleanor Herbert, Michelle Stewart, Marie Hutchison, Ann M Flenniken, Dawei Qu, Lauryl M J Nutter, Colin McKerlie, Liane Hobson, Brenda Kick, Bonnie L. Lyons, Jean-Paul Wiegand, Rosalinda A. Doty, Juan Antonio Aguilar-Pimentel, Martin Hrabe de Angelis, Mary Dickinson, John Seavitt, Jacqueline K White, Cheryl L Scudamore, and Sara Wells

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Low SATB1 Expression Promotes IL-5 and IL-9 Expression in Sézary Syndrome., Alberto Herrera, Simon Fredholm, Anthony Cheng, Eleni P Mimitou, Angelina Seffens, Michal Bar-Natan, Amy Sun, Jo-Ann Latkowski, Andreas Willerslew-Olsen, Terkild B Buus, Maria Gluud, Thorbjørn Krejsgaard, Sara Torres-Rusillo, Charlotte Menné Bonefeld, Anders Woetmann, Carsten Geisler, Larisa J Geskin, Zhengqing Ouyang, Peter Smibert, Niels Ødum, and Sergei B Koralov

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Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice., Sarah E Heuer, Sarah M Neuner, Niran Hadad, Kristen M S O'Connell, Robert W Williams, Vivek M. Philip, Chris Gaiteri, and Catherine Kaczorowski

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Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells., Yoshiki Higashijima, Yusuke Matsui, Teppei Shimamura, Ryo Nakaki, Nao Nagai, Shuichi Tsutsumi, Yohei Abe, Verena M Link, Mizuko Osaka, Masayuki Yoshida, Ryo Watanabe, Toshihiro Tanaka, Akashi Taguchi, Mai Miura, Xiaoan Ruan, Guoliang Li, Tsuyoshi Inoue, Masaomi Nangaku, Hiroshi Kimura, Tetsushi Furukawa, Hiroyuki Aburatani, Youichiro Wada, Yijun Ruan, Christopher K Glass, and Yasuharu Kanki

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Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation., Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace Stafford, Vivek Kohar, Leonard D. Shultz, and Michael V. Wiles

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Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils., Vishnu Hosur, Daniel A Skelly, Christopher Francis, Benjamin E. Low, Vivek Kohar, Lisa M. Burzenski, Mansoor M Amiji, Leonard D. Shultz, and Michael V. Wiles

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Decoding the mechanisms underlying cell-fate decision-making during stem cell differentiation by random circuit perturbation., Bin Huang, Mingyang Lu, Madeline Galbraith, Herbert Levine, Jose N Onuchic, and Dongya Jia

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FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity., Jonathan J Hubbard, Michal Pyzik, Timo Rath, Lisa K Kozicky, Kine M K Sand, Amit K Gandhi, Algirdas Grevys, Stian Foss, Susan C Menzies, Jonathan N Glickman, Edda Fiebiger, Derry C. Roopenian, Inger Sandlie, Jan Terje Andersen, Laura M Sly, Kristi Baker, and Richard S Blumberg

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Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells., Insoo Hyun, Megan Munsie, Martin F Pera, Nicolas C Rivron, and Janet Rossant

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Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology., Robert Ietswaart, Seda Arat, Amanda X Chen, Saman Farahmand, Bumjun Kim, William DuMouchel, Duncan Armstrong, Alexander Fekete, Jeffrey J Sutherland, and Laszlo Urban

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Integrating image caption information into biomedical document classification in support of biocuration., Xiangying Jiang, Pengyuan Li, James A. Kadin, Judith A. Blake, Martin Ringwald, and Hagit Shatkay

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MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instability., Peng Jia, Xiaofei Yang, Li Guo, Bowen Liu, Jiadong Lin, Hao Liang, Jianyong Sun, Chengsheng Zhang, and Kai Ye

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TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice., Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Laura Bongiovanni, Alain de Bruin, Dennis Beringer, Sanne van Dooremalen, Leonard D. Shultz, Fumihiko Ishikawa, Zsolt Sebestyen, Trudy Straetemans, and Jürgen Kuball

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STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells., Sascha Kahlfuss, Ulrike Kaufmann, Axel R Concepcion, Lucile Noyer, Dimitrius Raphael, Martin Vaeth, Jun Yang, Priya Pancholi, Mate Maus, James Muller, Lina Kozhaya, Alireza Khodadadi-Jamayran, Zhengxi Sun, Patrick Shaw, Derya Unutmaz, Peter B Stathopulos, Cori Feist, Scott B Cameron, Stuart E Turvey, and Stefan Feske

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HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis., Guy Karlebach, Peter Hansen, Diogo FT Veiga, Robin Steinhaus, Daniel Danis, Sheng Li, Olga Anczuków, and Peter N Robinson

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Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle., Ataur Katebi, Vivek Kohar, and Mingyang Lu

High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains., Brendan T Keenan, Raymond J Galante, Jie Lian, Petr Simecek, Daniel M. Gatti, Lin Zhang, Diane C Lim, Karen L. Svenson, Gary Churchill, and Allan I Pack

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Decoy exosomes provide protection against bacterial toxins., Matthew D Keller, Krystal L Ching, Feng-Xia Liang, Avantika Dhabaria, Kayan Tam, Beatrix M Ueberheide, Derya Unutmaz, Victor J Torres, and Ken Cadwell

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Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation., Eraj Shafiq Khokhar, Sneha Borikar, Elizabeth Eudy, Timothy M Stearns, Kira Young, and Jennifer J. Trowbridge

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Automated generation of gene summaries at the Alliance of Genome Resources., Ranjana Kishore, Valerio Arnaboldi, Ceri E Van Slyke, Juancarlos Chan, Robert S Nash, Jose M Urbano, Mary E. Dolan, Stacia R Engel, Mary Shimoyama, Paul W Sternberg, and The Alliance Of Genome Resources

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A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes., Heike Kollmus, Helmut Fuchs, Christoph Lengger, Hamed Haselimashhadi, Molly A. Bogue, Manuela A Östereicher, Marion Horsch, Thure Adler, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Johannes Beckers, Julia Calzada-Wack, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Tanja Klein-Rodewald, Holger Maier, Philipp Mayer-Kuckuk, Gregor Miller, Kristin Moreth, Frauke Neff, Birgit Rathkolb, Ildikó Rácz, Jan Rozman, Nadine Spielmann, Irina Treise, Dirk Busch, Jochen Graw, Thomas Klopstock, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Jeremy Mason, Arturo Torres, Mouse Phenome Database Team, Rudi Balling, Terry Mehaan, Valerie Gailus-Durner, Klaus Schughart, and Martin Hrabě de Angelis

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Systems biology of ferroptosis: A modeling approach., Anna Konstorum, Lia Tesfay, Bibbin T Paul, Frank M Torti, Reinhard Laubenbacher, and Suzy V Torti

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Implications of increased S100β and Tau5 proteins in dystrophic nerves of two mdx mouse models for Duchenne muscular dystrophy., Vidya S Krishnan, Annemieke Aartsma-Rus, Maurice Overzier, Cathleen Lutz, Laurent P. Bogdanik, and Miranda D Grounds

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Long non-coding RNAs in immune regulation and their potential as therapeutic targets., Dinesh Babu Uthaya Kumar and Adam Williams

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Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure., Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G Tolman, Syed Hameed, Yusef Seymens, Eric Dang, Anil K Mandal, Sirisha Senthil, Rohit C Khanna, Meha Kabra, Inderjeet Kaur, Simon W M John, Subhabrata Chakrabarti, and K Saidas Nair

From GWAS Association to Function: Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model., Feria A Ladha, Michael L. Stitzel, and J Travis Hinson

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Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal., Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L. Baker, Tracy C. McGarr, Christine A Wells, and Martin Pera

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V-SVA: an R Shiny application for detecting and annotating hidden sources of variation in single-cell RNA-seq data., Nathan Lawlor, Eladio J Marquez, Donghyung Lee, and Duygu Ucar

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LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia., Justin H Layer, Michael Christy, Lindsey Placek, Derya Unutmaz, Yan Guo, and Utpal P Davé

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Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients., Jihyun Lee, Suzanne D Vernon, Patricia Jeys, Weam Ali, Andrea Campos, Derya Unutmaz, Brayden Yellman, and Lucinda Bateman

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miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells., Clarice X Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A Flavell, Jorge Henao-Mejia, and Herbert Strobl

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GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells., thomas lisse, Manju Sharma, Neda Vishlaghi, Sri Ramulu N Pullagura, and Robert E Braun

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Addressing the batch effect issue for LC/MS metabolomics data in data preprocessing., Qin Liu, Douglas Walker, Karan Uppal, Zihe Liu, Chunyu Ma, ViLinh Tran, Shuzhao Li, Dean P Jones, and Tianwei Yu

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The Deep Genome Project., K C Kent Lloyd, David J Adams, Gareth Baynam, Arthur L Beaudet, Fatima Bosch, Kym M Boycott, Robert E Braun, Mark Caulfield, Ronald Cohn, Mary E Dickinson, Michael S Dobbie, Ann M Flenniken, Paul Flicek, Sanjeev Galande, Xiang Gao, Anne Grobler, Jason D Heaney, Yann Herault, Martin Hrabě de Angelis, James R Lupski, Stanislas Lyonnet, Ann-Marie Mallon, Fabio Mammano, Calum A MacRae, Roderick McInnes, Colin McKerlie, Terrence F Meehan, Stephen A Murray, Lauryl M J Nutter, Yuichi Obata, Helen Parkinson, Michael S Pepper, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Damian Smedley, Glauco Tocchini-Valentini, David Valle, Chi-Kuang Leo Wang, Sara Wells, Jacqueline K White, Wolfgang Wurst, Ying Xu, and Steve D M Brown

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LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding., Huacheng Luo, Qin Yu, Yang Liu, Ming Tang, Mingwei Liang, Dingpeng Zhang, Tsan Sam Xiao, Lizi Wu, Ming Tan, Yijun Ruan, Jörg Bungert, and Jianrong Lu

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Realizing the gains and losses in C9ORF72 ALS/FTD., Cathleen Lutz