Document Type

Article

Publication Date

7-9-2020

Keywords

JMG, JAXCC

JAX Source

Front Neuroscience 2020 Jul 9; 14:721

PMID

32742255

DOI

https://doi.org/10.3389/fnins.2020.00721

Grant

AA018776,DA043573,DA037927,DA39841,DA043809

Abstract

Substance use disorders are prevalent and present a tremendous societal cost but the mechanisms underlying addiction behavior are poorly understood and few biological treatments exist. One strategy to identify novel molecular mechanisms of addiction is through functional genomic experimentation. However, results from individual experiments are often noisy. To address this problem, the convergent analysis of multiple genomic experiments can discern signal from these studies. In the present study, we examine genetic loci that modulate the locomotor response to cocaine identified in the recombinant inbred (BXD RI) genetic reference population. We then applied the GeneWeaver software system for heterogeneous functional genomic analysis to integrate and aggregate multiple studies of addiction genomics, resulting in the identification of

Comments

We would like to thank Dr. Raymond F. Robledo technical assistance or all the brain dissections. We would also like to thank Dr. Brynn H. Voy, Dr. Arnold M. Saxton, and Dr. Matthew A. Cooper for their helpful comments on this research. Finally, we thank Stephen Krasinski for assistance with this manuscript.

This is an open access article distributed under the terms of the Creative Commons Attribution License.

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