Title

Mapping systemic lupus erythematosus heterogeneity at the single-cell level.

Document Type

Article

Publication Date

9-2020

Keywords

JGM, JAXCC

JAX Source

Nat Immunol 2020 Sep; 21(9):1094-1106

PMID

32747814

DOI

https://doi.org/10.1038/s41590-020-0743-0

Grant

CA034196

Abstract

Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~276,000 peripheral blood mononuclear cells from 33 children with SLE with different degrees of disease activity and 11 matched controls. Increased expression of interferon-stimulated genes (ISGs) distinguished cells from children with SLE from healthy control cells. The high ISG expression signature (ISG

Comments

We gratefully acknowledge the contribution of Flow Cytometry, Single Cell Biology and Genome Technologies Scientific Services at The Jackson Laboratory. In addition, we thank JAX Research IT (particularly Sandeep Namburi) for the support with maintaining the R Shiny application.

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