Title

Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human

Document Type

Article

Publication Date

12-8-2020

Keywords

JGM

JAX Source

Circulation 2020 Dec 8; 142(23):2262-2275

Volume

142

Issue

23

First Page

2262

Last Page

2275

ISSN

1524-4539

PMID

33025817

DOI

https://doi.org/10.1161/circulationaha.120.047999

Grant

HL125807; HL142787; EB028898; PRE343181021; PRE35110005

Abstract

BACKGROUND: Pathogenic

METHODS: We created a toolkit of human induced pluripotent stem cell models and functional assays using CRISPR/Cas9 to study

RESULTS: Hypertrophic cardiomyopathy-associated

CONCLUSIONS: Our study found that hypertrophic cardiomyopathy-associated

Comments

The authors thank A. Carcio and T. Prosio (The Jackson Laboratory for Genomic Medicine) for expertise in flow cytometry.

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