The Mouseion at the JAXlibrary

Title

Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human

Authors

Anthony M Pettinato, The Jackson LaboratoryFollow
Feria A Ladha, The Jackson LaboratoryFollow
David J Mellert, The Jackson LaboratoryFollow
Nicholas Legere
Rachel Cohn, The Jackson LaboratoryFollow
Robert Romano, The Jackson LaboratoryFollow
Ketan Thakar, The Jackson LaboratoryFollow
Yu-Sheng Chen
J Travis Hinson, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

12-8-2020

Keywords

JGM

JAX Source

Circulation 2020 Dec 8; 142(23):2262-2275

PMID

33025817

DOI

https://doi.org/10.1161/circulationaha.120.047999

Grant

HL125807; HL142787; EB028898; PRE343181021; PRE35110005

Abstract

BACKGROUND: Pathogenic

METHODS: We created a toolkit of human induced pluripotent stem cell models and functional assays using CRISPR/Cas9 to study

RESULTS: Hypertrophic cardiomyopathy-associated

CONCLUSIONS: Our study found that hypertrophic cardiomyopathy-associated

Comments

The authors thank A. Carcio and T. Prosio (The Jackson Laboratory for Genomic Medicine) for expertise in flow cytometry.

Recommended Citation

Pettinato, Anthony M; Ladha, Feria A; Mellert, David J; Legere, Nicholas; Cohn, Rachel; Romano, Robert; Thakar, Ketan; Chen, Yu-Sheng; and Hinson, J Travis, "Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human" (2020). Faculty Research 2020. 259.
https://mouseion.jax.org/stfb2020/259