Title
Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human
Document Type
Article
Publication Date
12-8-2020
Keywords
JGM
JAX Source
Circulation 2020 Dec 8; 142(23):2262-2275
PMID
33025817
DOI
https://doi.org/10.1161/circulationaha.120.047999
Grant
HL125807; HL142787; EB028898; PRE343181021; PRE35110005
Abstract
BACKGROUND: Pathogenic
METHODS: We created a toolkit of human induced pluripotent stem cell models and functional assays using CRISPR/Cas9 to study
RESULTS: Hypertrophic cardiomyopathy-associated
CONCLUSIONS: Our study found that hypertrophic cardiomyopathy-associated
Recommended Citation
Pettinato, Anthony M; Ladha, Feria A; Mellert, David J; Legere, Nicholas; Cohn, Rachel; Romano, Robert; Thakar, Ketan; Chen, Yu-Sheng; and Hinson, J Travis, "Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human" (2020). Faculty Research 2020. 259.
https://mouseion.jax.org/stfb2020/259
Comments
The authors thank A. Carcio and T. Prosio (The Jackson Laboratory for Genomic Medicine) for expertise in flow cytometry.