Document Type

Article

Publication Date

4-28-2020

Keywords

JMG

JAX Source

Elfie 2020 Apr 18; 9:e54318

Volume

9

ISSN

2050-084X

PMID

32342860

DOI

https://doi.org/10.7554/elife.54318

Grant

AG054180; AG038070

Abstract

Periodontal disease is an age-associated disorder clinically defined by periodontal bone loss, inflammation of the specialized tissues that surround and support the tooth, and microbiome dysbiosis. Currently, there is no therapy for reversing periodontal disease, and treatment is generally restricted to preventive measures or tooth extraction. The FDA-approved drug rapamycin slows aging and extends lifespan in multiple organisms, including mice. Here, we demonstrate that short-term treatment with rapamycin rejuvenates the aged oral cavity of elderly mice, including regeneration of periodontal bone, attenuation of gingival and periodontal bone inflammation, and revertive shift of the oral microbiome toward a more youthful composition. This provides a geroscience strategy to potentially rejuvenate oral health and reverse periodontal disease in the elderly.

Comments

This article is distributed under the terms of the Creative Commons Attribution License.

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