Document Type

Article

Publication Date

2-3-2020

Keywords

JMG

JAX Source

Genes Brain Behav 2020 Feb 3; e12645

PMID

32012419

DOI

https://doi.org/10.1111/gbb.12645

Abstract

Despite substantial evidence for sex differences in addiction epidemiology, addiction-relevant behaviors and associated neurobiological phenomena, the mechanisms and implications of these differences remain unknown. Genetic analysis in model organism is a potentially powerful and effective means of discovering the mechanisms that underlie sex differences in addiction. Human genetic studies are beginning to show precise risk variants that influence the mechanisms of addiction but typically lack sufficient power or neurobiological mechanistic access, particularly for the discovery of the mechanisms that underlie sex differences. Our thesis in this review is that genetic variation in model organisms are a promising approach that can complement these investigations to show the biological mechanisms that underlie sex differences in addiction.

Comments

Open access under the terms of the Creative Commons Attribution License

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