Title

Long non-coding RNAs in immune regulation and their potential as therapeutic targets.

Document Type

Article

Publication Date

2-11-2020

Keywords

JGM

JAX Source

Int Immunopharmacol 2020 Feb 11; 81:106279

PMID

32058929

DOI

https://doi.org/10.1016/j.intimp.2020.106279

Grant

AI141609,AI13522,AI13340

Abstract

Long non-coding RNAs (lncRNAs) are potent regulators of immune cell development and function. Their implication in multiple immune-mediated disorders highlights lncRNAs as exciting biomarkers and potential drug targets. Recent technological innovations in oligo-based therapeutics, development of RNA-targeting small molecules, and CRISPR-based approaches, position RNA as the next therapeutic frontier. Here, we review the latest advances made toward understanding the role of lncRNAs in human immunological disorders and further discuss RNA-targeting approaches that could be potentially exploited to manipulate lncRNA function as a clinical intervention.

Comments

We would like to thank Carmen Robinett for editing the manuscript, and Matt Wimsatt for illustration.

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