Document Type
Article
Publication Date
2-1-2020
Keywords
JMG
JAX Source
Mamm Genome 2020 Feb; 31(1-2):30-48
Volume
31
Issue
1-2
First Page
30
Last Page
48
ISSN
1432-1777
PMID
32060626
DOI
https://doi.org/10.1007/s00335-020-09827-3
Abstract
The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Here, we performed a comprehensive and comparative phenotyping screening to identify phenotypic differences and similarities between the eight founder strains. In total, more than 300 parameters including allergy, behavior, cardiovascular, clinical blood chemistry, dysmorphology, bone and cartilage, energy metabolism, eye and vision, immunology, lung function, neurology, nociception, and pathology were analyzed; in most traits from sixteen females and sixteen males. We identified over 270 parameters that were significantly different between strains. This study highlights the value of the founder and CC strains for phenotype-genotype associations of many genetic traits that are highly relevant to human diseases. All data described here are publicly available from the mouse phenome database for analyses and downloads.
Recommended Citation
Kollmus H,
Fuchs H,
Lengger C,
Haselimashhadi H,
Bogue MA,
Östereicher M,
Horsch M,
Adler T,
Aguilar-Pimentel J,
Amarie O,
Becker L,
Beckers J,
Calzada-Wack J,
Garrett L,
Hans W,
Hölter S,
Klein-Rodewald T,
Maier H,
Mayer-Kuckuk P,
Miller G,
Moreth K,
Neff F,
Rathkolb B,
Rácz I,
Rozman J,
Spielmann N,
Treise I,
Busch D,
Graw J,
Klopstock T,
Wolf E,
Wurst W,
Yildirim A,
Mason J,
Torres A,
Team MD,
Balling R,
Mehaan T,
Gailus-Durner V,
Schughart K,
Hrabě de Angelis M.
A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes. Mamm Genome 2020 Feb; 31(1-2):30-48
Comments
This open access article is licensed under a Creative Commons Attribution 4.0 International License