Title

Know Your Model: How essential is that essential gene?

Document Type

Article

Publication Date

1-2020

Keywords

JMG

JAX Source

Lab Anim (NY) 2020 Jan; 49(1):9-10

PMID

31802010

DOI

https://doi.org/10.1038/s41684-019-0444-1

Grant

HG000330

Abstract

Many studies have reported on the identification of ‘essential genes’ in mice, but the context of the experimental model, including genetic background and specific molecular details of the allele, may impact the influence of alleles on viability.

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