Title

EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma.

Document Type

Article

Publication Date

3-15-2020

Keywords

JGM

JAX Source

Clin Cancer Res 2020 Mar 15; 26(6):1395-1407

PMID

31852834

DOI

https://doi.org/10.1158/1078-0432.CCR-19-2549

Abstract

PURPOSE: Exploration of novel strategies to extend the benefit of PARP inhibitors beyond

EXPERIMENTAL DESIGN: Selective sensitivity to the PARP inhibitor talazoparib was screened and validated in two sets [test set (

RESULTS:

CONCLUSIONS:

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