Title

Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in

Document Type

Article

Publication Date

5-2020

Keywords

JGM

JAX Source

Antimicrob Agents Chemother 2020 May; 64(5):E00324-20

PMID

32122888

DOI

https://doi.org/10.1128/AAC.00324-20

Abstract

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying bla NDM-1 Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. bla NDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumanniistrains. A resistance gene island carrying bla PER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.

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