Document Type

Article

Publication Date

5-21-2020

Keywords

JMG, JGM, JAXCC

JAX Source

Immun Ageing 2020 May 21; 17:13.

PMID

32457811

DOI

https://doi.org/10.1186/s12979-020-00183-z

Grant

GM124922,AG048023,AG021600,AI089987

Abstract

While Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is disrupting lives across the globe for everyone, it has a more devastating impact on the health of older adults, especially that of older men. This pandemic has highlighted the crucial importance of considering an individual's age and biological sex in the clinic in addition to other confounding diseases (Kuchel, G.A, J Am Geriatr Soc, 67, 203, 2019, Tannenbaum, C., Nature, 575 451-458, 2009) As an interdisciplinary team of scientists in immunology, hematology, genomics, bioinformatics, and geriatrics, we have been studying how age and sex shape the human immune system. Herein we reflect on how our recent findings on the alterations of the immune system in aging might contribute to our current understanding of COVID-19 infection rate and disease risk.

Comments

We thank Taneli Helenius for aid in scientific writing, and Jane Cha for aid in the summary figure. We thank Virginia Pascual, Charles Lee, and Nadia Rosenthal for critical feedback.

This article is licensed under a Creative Commons Attribution 4.0 International License.

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