Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet.
Document Type
Article
Publication Date
5-4-2021
Publication Title
Cell Metab
Keywords
JGM
JAX Source
Cell Metab 2021 May 4; 33(5):873-887
Volume
33
Issue
5
First Page
873
Last Page
887
ISSN
1932-7420
PMID
33789092
DOI
https://doi.org/10.1016/j.cmet.2021.03.015
Grant
DA043809, AG060900
Abstract
The molecular circadian clock and symbiotic host-microbe relationships both evolved as mechanisms that enhance metabolic responses to environmental challenges. The gut microbiome benefits the host by breaking down diet-derived nutrients indigestible by the host and generating microbiota-derived metabolites that support host metabolism. Similarly, cellular circadian clocks optimize organismal physiology to the environment by influencing the timing and coordination of metabolic processes. Host-microbe interactions are influenced by dietary quality and timing, as well as daily light/dark cycles that entrain circadian rhythms in the host. Together, the gut microbiome and the molecular circadian clock play a coordinated role in neural processing, metabolism, adipogenesis, inflammation, and disease initiation and progression. This review examines the bidirectional interactions between the circadian clock, gut microbiota, and host metabolic systems and their effects on obesity and energy homeostasis. Directions for future research and the development of therapies that leverage these systems to address metabolic disease are highlighted.
Recommended Citation
Gutierrez Lopez D,
Lashinger L,
Weinstock GM,
Bray M.
Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet. Cell Metab 2021 May 4; 33(5):873-887