Document Type

Article

Publication Date

9-14-2021

Publication Title

Viruses

Keywords

JMG

JAX Source

Viruses 2021 Sep 14; 13(9):1823

Volume

13

Issue

9

ISSN

1999-4915

PMID

34578404

DOI

https://doi.org/10.3390/v13091823

Grant

DC016732, DC002756, AI011219

Abstract

Congenital Zika Syndrome (CZS) is caused by vertical transmission of Zika virus (ZIKV) to the gestating human fetus. A subset of CZS microcephalic infants present with reduced otoacoustic emissions; this test screens for hearing loss originating in the cochlea. This observation leads to the question of whether mammalian cochlear tissues are susceptible to infection by ZIKV during development. To address this question using a mouse model, the sensory cochlea was explanted at proliferative, newly post-mitotic or maturing stages. ZIKV was added for the first 24 h and organs cultured for up to 6 days to allow for cell differentiation. Results showed that ZIKV can robustly infect proliferating sensory progenitors, as well as post-mitotic hair cells and supporting cells. Virus neutralization using ZIKV-117 antibody blocked cochlear infection. AXL is a cell surface molecule known to enhance the attachment of flavivirus to host cells. While

Comments

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

Download

Share

COinS