Title

Hair follicle dystrophy in a litter of domestic cats resembling lanceolate hair mutant mice.

Document Type

Article

Publication Date

2-2021

Keywords

JMG

JAX Source

Vet Dermatol 2021 Feb; 32(1):74-e14

PMID

33470013

DOI

https://doi.org/10.1111/vde.12925

Grant

CA034196

Abstract

BACKGROUND: A new congenital hair-shaft abnormality resembling the lanceolate hair phenotype of rodents is described in a litter of four domestic short hair (DSH) cats. Data relating to hair shaft and follicle disorders remain scarce in veterinary medicine.

OBJECTIVES: To describe and compare structural abnormalities in these cats with other hair dystrophies in cats and other mammals.

ANIMALS: A DSH cat litter with progressive noninflammatory alopecia.

METHODS AND MATERIALS: Histopathological evaluation, scanning and transmission electron microscopy, and X-ray based element analysis defined the hair and skin changes in cats born with alopecia. Findings were compared to archival data from normal cats and lanceolate hair (Dsg4

RESULTS: Light and scanning electron microscopy of the hairs revealed lance- or spear-head shaped defects of the hair tip. Histological findings were swollen hair shafts, initially above the hair bulb matrix and later found in the distal parts of the telogen hair follicles, similar to those observed in Dsg4

CONCLUSION AND CLINICAL IMPORTANCE: A rare form of congenital alopecia resulting in follicular dystrophy is described in cats which is similar to hair follicle and hair-shaft changes reported in several mutant mouse strains with single gene mutations in adhesion molecules or keratin genes.

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