Investigation of oral, gastric, and duodenal microbiota in patients with upper gastrointestinal symptoms.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
J Investig Med 2021; 69:870-877
Disease-associated alterations of the intestinal microbiota composition, known as dysbiosis, have been well described in several functional gastrointestinal (GI) disorders. Several studies have described alterations in the gastric microbiota in functional dyspepsia, but very few have looked at the duodenum.Here, we explored the upper GI tract microbiota of inpatients with upper GI dyspeptic symptoms, and compared them to achalasia controls, as there is no indication for an esophagogastroduodenoscopy in healthy individuals.We found differences in the microbiota composition at the three sites evaluated (ie, saliva, stomach and duodenum). Changes observed in patients with dyspepsia included an increase in
Cervantes, Jorge; Michael, Majd; Hong, Bo-Young; Springer, Aden; Guo, Hua; Mendoza, Burgandy; Zeng, Mingtao; Sundin, Olof; and McCallum, Richard, "Investigation of oral, gastric, and duodenal microbiota in patients with upper gastrointestinal symptoms." (2021). Faculty Research 2021. 290.