Investigation of oral, gastric, and duodenal microbiota in patients with upper gastrointestinal symptoms.
Document Type
Article
Publication Date
2021
Publication Title
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Keywords
JGM
JAX Source
J Investig Med 2021; 69:870-877
Volume
69
First Page
870
Last Page
877
ISSN
1708-8267
PMID
33335025
DOI
https://doi.org/10.1136/jim-2020-001642
Abstract
Disease-associated alterations of the intestinal microbiota composition, known as dysbiosis, have been well described in several functional gastrointestinal (GI) disorders. Several studies have described alterations in the gastric microbiota in functional dyspepsia, but very few have looked at the duodenum.Here, we explored the upper GI tract microbiota of inpatients with upper GI dyspeptic symptoms, and compared them to achalasia controls, as there is no indication for an esophagogastroduodenoscopy in healthy individuals.We found differences in the microbiota composition at the three sites evaluated (ie, saliva, stomach and duodenum). Changes observed in patients with dyspepsia included an increase in
Recommended Citation
Cervantes J,
Michael M,
Hong B,
Springer A,
Guo H,
Mendoza B,
Zeng M,
Sundin O,
McCallum R.
Investigation of oral, gastric, and duodenal microbiota in patients with upper gastrointestinal symptoms. J Investig Med 2021; 69:870-877