Title

Investigation of oral, gastric, and duodenal microbiota in patients with upper gastrointestinal symptoms.

Document Type

Article

Publication Date

2021

Publication Title

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Keywords

JGM

JAX Source

J Investig Med 2021; 69:870-877

Volume

69

First Page

870

Last Page

877

ISSN

1708-8267

PMID

33335025

DOI

https://doi.org/10.1136/jim-2020-001642

Abstract

Disease-associated alterations of the intestinal microbiota composition, known as dysbiosis, have been well described in several functional gastrointestinal (GI) disorders. Several studies have described alterations in the gastric microbiota in functional dyspepsia, but very few have looked at the duodenum.Here, we explored the upper GI tract microbiota of inpatients with upper GI dyspeptic symptoms, and compared them to achalasia controls, as there is no indication for an esophagogastroduodenoscopy in healthy individuals.We found differences in the microbiota composition at the three sites evaluated (ie, saliva, stomach and duodenum). Changes observed in patients with dyspepsia included an increase in

Share

COinS