Aging (Albany NY)
JGM, Animals, Antineoplastic Agents, Apoptosis, Cell Proliferation, Drug Delivery Systems, ErbB Receptors, Hep G2 Cells, Humans, Liver, Liver Neoplasms, Mice, Mice, Nude, Nanotubes, Carbon, Neoplasm Transplantation, RNA, Small Interfering, Sorafenib
Aging (Albany NY) 2021 Jan 13; 13(2):1872-1882
OBJECTIVE: This study aimed to investigate the effects of multiwalled carbon nanotubes (MWNTs) co-delivering sorafenib (Sor) and epidermal growth factor receptor (EGFR) siRNA (MWNT/Sor/siRNA) on tumor growth in liver cancer (LC).
RESULTS: MWNT/Sor/siRNA was proved to possess increased Sor release, high siRNA stability, and enhanced cellular uptake. In addition, MWNT treatment has few effects on cell proliferation and apoptosis in HepG2 cells; however, MWNT/Sor/siRNA treatment significantly inhibited clone number and induced cell apoptosis, which shows a more favorable antitumor effect than MWNT/Sor and free Sor and free siRNA in HepG2 cells. Moreover MWNT/Sor/siRNA treatment has the most significant antitumor effect
CONCLUSIONS: MWNT/Sor/siRNA exhibited a superior antitumor effect
METHODS: The MWNT/Sor and MWNT/Sor/siRNA were prepared, and then the morphologies of MWNT/Sor/siRNA were analyzed.
Wen, Zhili; Feng, Yuliang; Hu, Youwen; Lian, Lingyan; Huang, Hongyan; Guo, Li; Chen, Shanwen; Yang, Qian; Zhang, Moran; Wan, Lijun; Xu, Kedong; Degejirifu; and Yan, Xiaohua, "Multiwalled carbon nanotubes co-delivering sorafenib and epidermal growth factor receptor siRNA enhanced tumor-suppressing effect on liver cancer." (2021). Faculty Research 2021. 301.