Document Type

Article

Publication Date

2-19-2021

Keywords

JMG

JAX Source

Int J Mol Sci 2021 Feb 19; 22(4):2071

Volume

22

Issue

4

ISSN

1422-0067

PMID

33669808

DOI

https://doi.org/10.3390/ijms22042071

Grant

CA034196, GM104318, AG022308, AI145383, The Foundation Leducq Transatlantic Network of Excellence in Cardiac Research and the Director’s Innovation Fund at The Jackson Laboratory.

Abstract

Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to characterize the heart at high cellular resolution. Single-cell profiling provides a more precise definition of tissue composition, cell differentiation trajectories, and intercellular communication, compared to classical bulk approaches. Here, we aim to review how recent single-cell multi-omic studies have changed our understanding of cell dynamics during cardiac development, and in the healthy and diseased adult myocardium.

Comments

We acknowledge use and support of The Jackson Laboratory Scientific Services as well as The Jackson Laboratory Creative Team, specifically Karen Davis for the realization of the graphical abstract.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

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