Title

Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH.

Document Type

Article

Publication Date

4-7-2021

Publication Title

Neuron

Keywords

JGM, Alzheimer Disease, Genetic Engineering, Humans, Induced Pluripotent Stem Cells, Neural Stem Cells, Neurodegenerative Diseases, Stem Cell Research, Stem Cell Transplantation

JAX Source

Neuron 2021 Apr 7; 109(7):1080-1083

Volume

109

Issue

7

First Page

1080

Last Page

1083

ISSN

1097-4199

PMID

33831364

DOI

https://doi.org/10.1016/j.neuron.2021.03.022

Abstract

The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.

Comments

We thank Erika Lara Flores, Andy Qi, Luke Reilly, Mike Nalls, Lirong Peng, Faraz Faghri, Jizhong Zou, Kailyn Anderson, Julia Stadler, Caroline Pantazis, Bruce Conklin, the Chan Zuckerberg Initiative, and the Allen Institute for their helpful input on this project and manuscript.

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