Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH.
JGM, Alzheimer Disease, Genetic Engineering, Humans, Induced Pluripotent Stem Cells, Neural Stem Cells, Neurodegenerative Diseases, Stem Cell Research, Stem Cell Transplantation
Neuron 2021 Apr 7; 109(7):1080-1083
The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
Ramos, Daniel M; Skarnes, William C; Singleton, Andrew B; Cookson, Mark R; and Ward, Michael E, "Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH." (2021). Faculty Research 2021. 84.