Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study.
The American journal of medicine
JGM, Antibodies, Viral, Attitude to Health, COVID-19, COVID-19 Serological Testing, Connecticut, Ethnic Groups, Female, Humans, Immunoglobulin G, Male, Middle Aged, Needs Assessment, Prevalence, Risk Reduction Behavior, SARS-CoV-2, Seroepidemiologic Studies
Am J Med 2021 Apr; 134(4):526-534.e11
BACKGROUND: A seroprevalence study can estimate the percentage of people with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the general population; however, most existing reports have used a convenience sample, which may bias their estimates.
METHODS: We sought a representative sample of Connecticut residents, ages ≥18 years and residing in noncongregate settings, who completed a survey between June 4 and June 23, 2020, and underwent serology testing for SARS-CoV-2-specific immunoglobulin G (IgG) antibodies between June 10 and July 29, 2020. We also oversampled non-Hispanic black and Hispanic subpopulations. We estimated the seroprevalence of SARS-CoV-2-specific IgG antibodies and the prevalence of symptomatic illness and self-reported adherence to risk-mitigation behaviors among this population.
RESULTS: Of the 567 respondents (mean age 50 [± 17] years; 53% women; 75% non-Hispanic white individuals) included at the state level, 23 respondents tested positive for SARS-CoV-2-specific antibodies, resulting in weighted seroprevalence of 4.0 (90% confidence interval [CI] 2.0-6.0). The weighted seroprevalence for the oversampled non-Hispanic black and Hispanic populations was 6.4% (90% CI 0.9-11.9) and 19.9% (90% CI 13.2-26.6), respectively. The majority of respondents at the state level reported following risk-mitigation behaviors: 73% avoided public places, 75% avoided gatherings of families or friends, and 97% wore a facemask, at least part of the time.
CONCLUSIONS: These estimates indicate that the vast majority of people in Connecticut lack antibodies against SARS-CoV-2, and there is variation by race and ethnicity. There is a need for continued adherence to risk-mitigation behaviors among Connecticut residents to prevent resurgence of COVID-19 in this region.
Mahajan, Shiwani; Srinivasan, Rajesh; Redlich, Carrie A; Huston, Sara K; Anastasio, Kelly M; Cashman, Lisa; Massey, Dorothy S; Dugan, Andrew; Witters, Dan; Marlar, Jenny; Li, Shu-Xia; Lin, Zhenqiu; Hodge, Domonique; Chattopadhyay, Manas; Adams, Mark D; Lee, Charles; Rao, Lokinendi V; Stewart, Chris; Kuppusamy, Karthik; Ko, Albert I; and Krumholz, Harlan M, "Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study." (2021). Faculty Research 2021. 90.