Document Type

Article

Publication Date

6-23-2022

Publication Title

PLoS One

Keywords

Brain Neoplasms, Cdc20 Proteins, Cell Cycle Proteins, Cell Line, Tumor, Glioblastoma, Humans, Neoplasm Recurrence, Local, Neoplastic Stem Cells

JAX Source

PLoS One 2022 Jun 23; 17(6):e0270251

Volume

17

Issue

6

First Page

0270251

Last Page

0270251

ISSN

1932-6203

PMID

35737702

DOI

https://doi.org/10.1371/journal.pone.0270251

Abstract

Glioblastoma stem cells (GSCs) are an important subpopulation in glioblastoma, implicated in tumor growth, tumor recurrence, and radiation resistance. Understanding the cellular mechanisms for chemo- and radiation resistance could lead to the development of new therapeutic strategies. Here, we demonstrate that CDC20 promotes resistance to chemotherapy and radiation therapy. CDC20 knockdown does not increase TMZ- and radiation-induced DNA damage, or alter DNA damage repair, but rather promotes cell death through accumulation of the pro-apoptotic protein, Bim. Our results identify a CDC20 signaling pathway that regulates chemo- and radiosensitivity in GSCs, with the potential for CDC20-targeted therapeutic strategies in the treatment of glioblastoma.

Comments

This is an open access article under the CC BY-NC-ND license

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