Brain Neoplasms, Cdc20 Proteins, Cell Cycle Proteins, Cell Line, Tumor, Glioblastoma, Humans, Neoplasm Recurrence, Local, Neoplastic Stem Cells
PLoS One 2022 Jun 23; 17(6):e0270251
Glioblastoma stem cells (GSCs) are an important subpopulation in glioblastoma, implicated in tumor growth, tumor recurrence, and radiation resistance. Understanding the cellular mechanisms for chemo- and radiation resistance could lead to the development of new therapeutic strategies. Here, we demonstrate that CDC20 promotes resistance to chemotherapy and radiation therapy. CDC20 knockdown does not increase TMZ- and radiation-induced DNA damage, or alter DNA damage repair, but rather promotes cell death through accumulation of the pro-apoptotic protein, Bim. Our results identify a CDC20 signaling pathway that regulates chemo- and radiosensitivity in GSCs, with the potential for CDC20-targeted therapeutic strategies in the treatment of glioblastoma.
CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells. PLoS One 2022 Jun 23; 17(6):e0270251