State of Residency: Microbial Strain Diversity in the Skin.

Document Type

Article

Publication Date

5-2022

Publication Title

The Journal of investigative dermatology

Keywords

JGM, Humans, Internship and Residency, Microbiota, Skin

JAX Source

J Invest Dermatol 2022 May; 142(5):1260-1264

Volume

142

Issue

5

First Page

1260

Last Page

1264

ISSN

1523-1747

PMID

34688614

DOI

https://doi.org/10.1016/j.jid.2021.10.005

Grant

AR078634, GM126893, AI142733, AR075174

Abstract

Human skin hosts a diversity of microbiota. Advances in sequencing and analytical methods have increasingly illuminated the importance of the finest resolution in understanding the genetic diversity of the skin microbiota, highlighting strain-level differences and their functional implications. Such genetic diversity, which exists within an individual and is strongly individual specific underscores the difficulty in elucidating functionality. Integrated investigations of the microbial strain diversity through sequencing and culture-based approaches with host immunology and physiology will be critical in expanding our understanding of the roles of the skin microbiome.

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