Molecular genetic mechanisms of dilated cardiomyopathy.

Document Type

Article

Publication Date

10-2022

Publication Title

Current opinion in genetics & development

Keywords

JGM

JAX Source

Curr Opin Genet Dev 2022 Oct; 76:101959

Volume

76

First Page

101959

Last Page

101959

ISSN

1879-0380

PMID

35870234

DOI

https://doi.org/10.1016/j.gde.2022.101959

Abstract

Heart failure (HF) is a rapidly growing cardiovascular condition with a prevalence of ~40 million individuals worldwide [1]. While HF can be caused by acquired conditions such as myocardial infarctions and viruses [2], the genetic basis for HF is rapidly emerging particularly for dilated cardiomyopathy (DCM) that is the most prevalent HF type. In this review, insights from the rapid expansion in next-generation sequencing technologies applied in the HF clinic are merged with recent functional genomics studies to provide a contemporary view of DCM molecular genetics.

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