Molecular genetic mechanisms of dilated cardiomyopathy.
Current opinion in genetics & development
Curr Opin Genet Dev 2022 Oct; 76:101959
Heart failure (HF) is a rapidly growing cardiovascular condition with a prevalence of ~40 million individuals worldwide . While HF can be caused by acquired conditions such as myocardial infarctions and viruses , the genetic basis for HF is rapidly emerging particularly for dilated cardiomyopathy (DCM) that is the most prevalent HF type. In this review, insights from the rapid expansion in next-generation sequencing technologies applied in the HF clinic are merged with recent functional genomics studies to provide a contemporary view of DCM molecular genetics.
Molecular genetic mechanisms of dilated cardiomyopathy. Curr Opin Genet Dev 2022 Oct; 76:101959