Document Type
Article
Publication Date
4-4-2022
Publication Title
Genetics
Keywords
JMG, Alleles, Animals, Caenorhabditis elegans, Databases, Genetic, Drosophila, Gene Ontology, Humans, Internet, Mice, Molecular Sequence Annotation, Rats, Saccharomycetales, Zebrafish
JAX Source
Genetics 2022 Apr; 220(4):iyac022
Volume
220
Issue
4
ISSN
1943-2631
PMID
35380658
DOI
https://doi.org/10.1093/genetics/iyac022
Abstract
The Alliance of Genome Resources (the Alliance) is a combined effort of 7 knowledgebase projects: Saccharomyces Genome Database, WormBase, FlyBase, Mouse Genome Database, the Zebrafish Information Network, Rat Genome Database, and the Gene Ontology Resource. The Alliance seeks to provide several benefits: better service to the various communities served by these projects; a harmonized view of data for all biomedical researchers, bioinformaticians, clinicians, and students; and a more sustainable infrastructure. The Alliance has harmonized cross-organism data to provide useful comparative views of gene function, gene expression, and human disease relevance. The basis of the comparative views is shared calls of orthology relationships and the use of common ontologies. The key types of data are alleles and variants, gene function based on gene ontology annotations, phenotypes, association to human disease, gene expression, protein-protein and genetic interactions, and participation in pathways. The information is presented on uniform gene pages that allow facile summarization of information about each gene in each of the 7 organisms covered (budding yeast, roundworm Caenorhabditis elegans, fruit fly, house mouse, zebrafish, brown rat, and human). The harmonized knowledge is freely available on the alliancegenome.org portal, as downloadable files, and by APIs. We expect other existing and emerging knowledge bases to join in the effort to provide the union of useful data and features that each knowledge base currently provides.
Recommended Citation
Resources Consortium AG,
Anagnostopoulos AV,
Bello SM,
Blake JA,
Blodgett O,
Bult CJ,
Christie KR,
Dolan ME,
Hale P,
Kadin JA,
McAndrews MS,
Motenko H,
Shaw DR,
Smith CM,
Smith CL,
Tomczuk M,
Wilming LG.
Harmonizing model organism data in the Alliance of Genome Resources. Genetics 2022 Apr; 220(4):iyac022
Comments
Jackson Laboratory authors listed above are all members of the Alliance of Genome Resources Consortium. A complete list of authors is available at the end of the article.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License.