Document Type

Article

Publication Date

10-7-2022

Publication Title

Nat Commun

Keywords

JGM, Genome, Genomics, Humans, Neoplasms

JAX Source

Nat Commun. 2022;13(1):5908

Volume

13

Issue

1

First Page

5908

Last Page

5908

ISSN

2041-1723

PMID

36207330

DOI

https://doi.org/10.1038/s41467-022-33717-8

Grant

F.M. and E.T.L. gratefully acknowledge financial support from the U.S. National Cancer Institute (grants P30CA034196 and R01CA255705).

Abstract

Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities beyond the original paradigm of one gene-one phenotype.

Comments

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Download

Share

COinS