JGM, Genome, Genomics, Humans, Neoplasms
Nat Commun. 2022;13(1):5908
F.M. and E.T.L. gratefully acknowledge financial support from the U.S. National Cancer Institute (grants P30CA034196 and R01CA255705).
Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities beyond the original paradigm of one gene-one phenotype.
Functional genomics of complex cancer genomes. Nat Commun. 2022;13(1):5908