Document Type
Article
Publication Date
11-4-2022
Publication Title
Microbiome
Keywords
JGM, Humans, Mice, Animals, Bifidobacterium, Nucleosides, Oxidative Phosphorylation, Obesity, Diet, High-Fat, Bifidobacterium longum, Adipose Tissue, White
JAX Source
Microbiome. 2022;10(1):188
Volume
10
Issue
1
First Page
188
Last Page
188
ISSN
2049-2618
PMID
36333752
DOI
https://doi.org/10.1186/s40168-022-01374-0
Abstract
BACKGROUND: Comparisons of the gut microbiome of lean and obese humans have revealed that obesity is associated with the gut microbiome plus changes in numerous environmental factors, including high-fat diet (HFD). Here, we report that two species of Bifidobacterium are crucial to controlling metabolic parameters in the Korean population.
RESULTS: Based on gut microbial analysis from 99 Korean individuals, we observed the abundance of Bifidobacterium longum and Bifidobacterium bifidum was markedly reduced in individuals with increased visceral adipose tissue (VAT), body mass index (BMI), blood triglyceride (TG), and fatty liver. Bacterial transcriptomic analysis revealed that carbohydrate/nucleoside metabolic processes of Bifidobacterium longum and Bifidobacterium bifidum were associated with protecting against diet-induced obesity. Oral treatment of specific commercial Bifidobacterium longum and Bifidobacterium bifidum enhanced bile acid signaling contributing to potentiate oxidative phosphorylation (OXPHOS) in adipose tissues, leading to reduction of body weight gain and improvement in hepatic steatosis and glucose homeostasis. Bifidobacterium longum or Bifidobacterium bifidum manipulated intestinal sterol biosynthetic processes to protect against diet-induced obesity in germ-free mice.
CONCLUSIONS: Our findings support the notion that treatment of carbohydrate/nucleoside metabolic processes-enriched Bifidobacterium longum and Bifidobacterium bifidum would be a novel therapeutic strategy for reprograming the host metabolic homeostasis to protect against metabolic syndromes, including diet-induced obesity. Video Abstract.
Recommended Citation
Kim G,
Yoon Y,
Park J,
Park J,
Noh M,
Kim H,
Park C,
Kwon H,
Park J,
Kim Y,
Sohn J,
Park S,
Kim H,
Im S,
Kim Y,
Chung H,
Nam M,
Kwon J,
Kim I,
Kim Y,
Baek J,
Kim H,
Weinstock G,
Cho B,
Lee C,
Fang S,
Park H,
Seong J.
Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity. Microbiome. 2022;10(1):188
Comments
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