Frailty-associated dysbiosis of human microbiotas in older adults in nursing homes

Julia Oh, Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Julie Robison
George A. Kuchel

Abstract

Our longitudinal study comparing the skin, gut and oral microbiomes of community-dwelling older adults and nursing home residents showed striking changes known to be linked to antibiotic resistance and disease risk. Such shifts were associated with frailty, not chronological age, and were most pronounced in the skin, the primary reservoir for infection risk.