iScience 2022 Jan 25; 25(2):103814
Proper gene regulation is critical for both neuronal development and maintenance as the brain matures. We previously demonstrated that Akirin2, an essential nuclear protein that interacts with transcription factors and chromatin remodeling complexes, is required for the embryonic formation of the cerebral cortex. Here we show that Akirin2 plays a mechanistically distinct role in maintaining healthy neurons during cortical maturation. Restricting Akirin2 loss to excitatory cortical neurons resulted in progressive neurodegeneration via necroptosis and severe cortical atrophy with age. Comparing transcriptomes from Akirin2-null postnatal neurons and cortical progenitors revealed that targets of the tumor suppressor p53, a regulator of both proliferation and cell death encoded by
Peek, Stacey L; Bosch, Peter J; Bahl, Ethan; Iverson, Brianna J; Parida, Mrutyunjaya; Bais, Preeti; Manak, J Robert; Michaelson, Jacob J; Burgess, Robert W.; and Weiner, Joshua A, "p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2." (2022). Faculty Research 2022. 31.