Document Type

Article

Publication Date

5-1-2022

Publication Title

Trends in neurosciences

Keywords

JMG, Alzheimer Disease, Animals, Brain, Cognition, Humans, Mice, Protein Processing, Post-Translational, Resilience, Psychological

JAX Source

Trends Neurosci 2022 May; 45(5):369-383

Volume

45

Issue

5

First Page

369

Last Page

383

ISSN

1878-108X

PMID

35307206

DOI

https://doi.org/10.1016/j.tins.2022.02.005

Grant

AG057914, AG054180, AG063755, AG059778, A2016397S, ZEN-21-846037

Abstract

Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-associated pathology are said to be 'resilient' to AD. Identifying mechanisms underlying resilience represents an exciting therapeutic opportunity. Human studies have identified a number of molecular and genetic factors associated with resilience, but the complexity of these cohorts prohibits a complete understanding of which factors are causal or simply correlated with resilience. Genetically and phenotypically diverse mouse models of AD provide new and translationally relevant opportunities to identify and prioritize new resilience mechanisms for further cross-species investigation. This review will discuss insights into resilience gained from both human and animal studies and highlight future approaches that may help translate these insights into therapeutics designed to prevent or delay AD-related dementia.

Comments

This is an open access article under the CC BY licens

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