iScience. 2022 May 20;25(5):104309.
MicroRNAs (miRNAs) have been shown to play important roles in viral infections, but their associations with SARS-CoV-2 infection remain poorly understood. Here, we detected 85 differentially expressed miRNAs (DE-miRNAs) from 2,336 known and 361 novel miRNAs that were identified in 233 plasma samples from 61 healthy controls and 116 patients with COVID-19 using the high-throughput sequencing and computational analysis. These DE-miRNAs were associated with SASR-CoV-2 infection, disease severity, and viral persistence in the patients with COVID-19, respectively. Gene ontology and KEGG pathway analyses of the DE-miRNAs revealed their connections to viral infections, immune responses, and lung diseases. Finally, we established a machine learning model using the DE-miRNAs between various groups for classification of COVID-19 cases with different clinical presentations. Our findings may help understand the contribution of miRNAs to the pathogenesis of COVID-19 and identify potential biomarkers and molecular targets for diagnosis and treatment of SARS-CoV-2 infection.
Zeng, Qiqi; Qi, Xin; Ma, Junpeng; Hu, Fang; Wang, Xiaorui; Qin, Hongyu; Li, Mengyang; Huang, Shaoxin; Yang, Yong; Li, Yixin; Bai, Han; Jiang, Meng; Ren, Doudou; Kang, Ye; Zhao, Yang; Chen, Xiaobei; Ding, Xi; Ye, Di; Wang, Yankui; Jiang, Jianguo; Li, Dong; Chen, Xi; Hu, Ke; Zhang, Binghong; Shi, Bingyin; and Zhang, Chengsheng, "Distinct miRNAs associated with various clinical presentations of SARS-CoV-2 infection." (2022). Faculty Research 2022. 59.