Document Type

Article

Publication Date

5-20-2022

Publication Title

iScience

Keywords

JGM

JAX Source

iScience. 2022 May 20;25(5):104309.

Volume

25

Issue

5

First Page

104309

Last Page

104309

ISSN

2589-0042

PMID

35502319

DOI

https://doi.org/10.1016/j.isci.2022.104309

Abstract

MicroRNAs (miRNAs) have been shown to play important roles in viral infections, but their associations with SARS-CoV-2 infection remain poorly understood. Here, we detected 85 differentially expressed miRNAs (DE-miRNAs) from 2,336 known and 361 novel miRNAs that were identified in 233 plasma samples from 61 healthy controls and 116 patients with COVID-19 using the high-throughput sequencing and computational analysis. These DE-miRNAs were associated with SASR-CoV-2 infection, disease severity, and viral persistence in the patients with COVID-19, respectively. Gene ontology and KEGG pathway analyses of the DE-miRNAs revealed their connections to viral infections, immune responses, and lung diseases. Finally, we established a machine learning model using the DE-miRNAs between various groups for classification of COVID-19 cases with different clinical presentations. Our findings may help understand the contribution of miRNAs to the pathogenesis of COVID-19 and identify potential biomarkers and molecular targets for diagnosis and treatment of SARS-CoV-2 infection.

Comments

This is an open access article under the CC BY-NC-ND license.

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