Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.
Investigative ophthalmology & visual science
JMG, Animals, Aqueous Humor, Consensus, Disease Models, Animal, Glaucoma, Intraocular Pressure, Mice, Ocular Hypertension, Tonometry, Ocular, Trabecular Meshwork
Invest Ophthalmol Vis Sci 2022 Feb 1; 63(2):12
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
van Batenburg-Sherwood J,
De Ieso M,
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci 2022 Feb 1; 63(2):12
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