Document Type
Article
Publication Date
1-3-2022
Publication Title
Front Genet
Keywords
JGM
JAX Source
Front Genet 2022 Jan 3; 12:778416
Volume
12
First Page
778416
Last Page
778416
ISSN
1664-8021
PMID
35047007
DOI
https://doi.org/10.3389/fgene.2021.778416
Abstract
We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These extracellular RNA (exRNA) play a role in intercellular signaling, serve as biomarkers of disease, and form the basis of new strategies for disease treatment. The Extracellular RNA Communication Consortium (ERCC) hosted a two-day online workshop (April 19-20, 2021) on the unique challenges of exRNA data analysis. The goal was to foster an open dialog about best practices and discuss open problems in the field, focusing initially on small exRNA sequencing data. Video recordings of workshop presentations and discussions are available (https://exRNA.org/exRNAdata2021-videos/). There were three target audiences: experimentalists who generate exRNA sequencing data, computational and data scientists who work with those groups to analyze their data, and experimental and data scientists new to the field. Here we summarize issues explored during the workshop, including progress on an effort to develop an exRNA data analysis challenge to engage the community in solving some of these open problems.
Recommended Citation
Alexander R,
Kitchen R,
Tosar J,
Roth M,
Mestdagh P,
Max K,
Rozowsky J,
Kaczor-Urbanowicz K,
Chang J,
Balaj L,
Losic B,
Van Nostrand E,
LaPlante E,
Mateescu B,
White B,
Yu R,
Milosavljevic A,
Stolovitzky G,
Spengler R.
Open Problems in Extracellular RNA Data Analysis: Insights From an ERCC Online Workshop. Front Genet 2022 Jan 3; 12:778416
Comments
This is an open-access article distributed under the terms of the Creative Commons Attribution License.