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JMG, Humans, Reproducibility of Results, Stem Cell Research

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Stem Cell Reports. 2023;18(9):1744-52.







This work was supported by the Burroughs Wellcome Fund, the Doris Duke Charitable Foundation, and the Simons Foundation Autism Research Initiative. Additional support to authors provided by the Arto Hardy Family (to J.M.C.); The Novo Nordisk Founda- tion Center for Stem Cell Medicine, which is supported by the Novo Nordisk Foundation (NNF21CC0073729 to K.B.J. and C.L.M.); the Medical Research Council Professor Award (G1100526/2 to A.G.S.); the Medical Research Council (MR/ X000028/1 and MR/X007979/1 to I.B.); the UK Regenerative Med- icine Platform (MR/R015724/1 to I.B.); The Francis Crick Institute, which receives its funding from Cancer Research UK (CC0199 to L.E.H.); the UK Medical Research Council (CC0199 to L.E.H.); the Wellcome Trust (CC0199 to L.E.H.); the Medical Research Council (MC_UP_1201/9) and the European Research Council (ERC STG 757710) (M.A.L.); the Korean Fund for Regenerative Medicine (funded by Ministry of Science and ICT) and Ministry of Health and Welfare, Republic of Korea (RS-2022-00070674, to J.S.); and the National Research Foundation of Korea grant funded by the Korean government (MSIT) (no. 2020M3A9E4037903 to J.S.).


The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research to be accurate, meaningful, and durable, standards that ensure reproducibility and reliability of the data should be applied. Although such standards have been previously proposed for repositories and distribution centers, no widely accepted best practices exist for laboratory research with human pluripotent and tissue stem cells. To fill that void, the International Society for Stem Cell Research has developed a set of recommendations, including reporting criteria, for scientists in basic research laboratories. These criteria are designed to be technically and financially feasible and, when implemented, enhance the reproducibility and rigor of stem cell research.


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