Hematopoietic stem cell aging and leukemia transformation.
Colom Díaz P,
Hematopoietic stem cell aging and leukemia transformation. Blood. 2023;142(6):533-42.
JMG, Humans, Aged, Cellular Senescence, Aging, Hematopoietic Stem Cells, Leukemia, Hematopoiesis, Hematologic Neoplasms
This work was supported by National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases grant R01DK118072 (J.J.T.) and NIH National Institute on Aging grants R01AG069010 and U01AG077925 (J.J.T.). J.J.T. is a Scholar of the Leukemia & Lymphoma Society. J.J.M. is supported by a scholar award from The Jackson Laboratory.
With aging, hematopoietic stem cells (HSCs) have an impaired ability to regenerate, differentiate, and produce an entire repertoire of mature blood and immune cells. Owing to dysfunctional hematopoiesis, the incidence of hematologic malignancies increases among elderly individuals. Here, we provide an update on HSC-intrinsic and -extrinsic factors and processes that were recently discovered to contribute to the functional decline of HSCs during aging. In addition, we discuss the targets and timing of intervention approaches to maintain HSC function during aging and the extent to which these same targets may prevent or delay transformation to hematologic malignancies.