A brief chronicle of research on human pluripotent stem cells.
Document Type
Article
Publication Date
12-1-2024
Original Citation
Pera M.
A brief chronicle of research on human pluripotent stem cells. Bioessays. 2024;46(12):e2400092.
Keywords
JMG, Humans, Pluripotent Stem Cells, Animals, Gene Editing, Cell Culture Techniques
JAX Source
Bioessays. 2024;46(12):e2400092.
ISSN
1521-1878
PMID
39058898
DOI
https://doi.org/10.1002/bies.202400092
Abstract
Today, human pluripotent stem cell technologies find widespread application across biomedical research, as models for early human development, as platforms for functional human genomics, as tools for the study of disease, drug screening and toxicology, and as a renewable source of cellular therapeutics for a range of intractable diseases. The foundations of this human pluripotent stem cell revolution rest on advances in a wide range of disciplines, including cancer biology, assisted reproduction, cell culture and organoid technology, somatic cell nuclear transfer, primate embryology, single-cell biology, and gene editing. This review surveys the slow emergence of the study of human pluripotency and the exponential growth of the field during the past several decades.