Histone Modifications and Their Contributions to Hypertension.
Document Type
Article
Publication Date
2-1-2024
Original Citation
Ray A,
Stelloh C,
Liu Y,
Meyer A,
Geurts A,
Cowley A,
Greene A,
Liang M,
Rao S.
Histone Modifications and Their Contributions to Hypertension. Hypertension. 2024 Feb;81(2):229-239.
Keywords
JMG, Animals, Histone Code, Histones, Hypertension, Essential Hypertension, Protein Processing, Post-Translational, Epigenesis, Genetic
JAX Source
Hypertension. 2024 Feb;81(2):229-239.
ISSN
1524-4563
PMID
38031837
DOI
https://doi.org/10.1161/hypertensionaha.123.21755
Grant
The work of A.M. Geurts, A. Cowley, A.S. Greene, M. Liang, and S. Rao was sup- ported by the National Heart, Lung, and Blood Institute (Human and Health Services, National Institute of Health; P01HL149620).
Abstract
Essential hypertension, a multifaceted disorder, is a worldwide health problem. A complex network of genetic, epigenetic, physiological, and environmental components regulates blood pressure (BP), and any dysregulation of this network may result in hypertension. Growing evidence suggests a role for epigenetic factors in BP regulation. Any alterations in the expression or functions of these epigenetic regulators may dysregulate various determinants of BP, thereby promoting the development of hypertension. Histone posttranslational modifications are critical epigenetic regulators that have been implicated in hypertension. Several studies have demonstrated a clear association between the increased expression of some histone-modifying enzymes, especially HDACs (histone deacetylases), and hypertension. In addition, treatment with HDAC inhibitors lowers BP in hypertensive animal models, providing an excellent opportunity to design new drugs to treat hypertension. In this review, we discuss the potential contribution of different histone modifications to the regulation of BP.